TY - JOUR

T1 - Нейрокогнитивный профиль, негативные и аффективные симптомы при шизофрении: структура и взаимосвязи.

AU - Петрова, Наталия Николаевна

PY - 2023/7/11

Y1 - 2023/7/11

N2 - The paper presents the results of a study of the severity, structure and relationships of negative, affective and cognitive disorders in 40 patients with schizophrenia as an example. A clinical scale assessment was used. In the structure of a markedly pronounced neurocognitive deficit in patients with schizophrenia, disturbances in auditory-verbal memory, executive functions, and attention predominate. Neurocognitive deficit, in particular, the deterioration of executive functions, increases with the duration of the disease. Negative symptoms are moderately expressed with the dominance of anhedonia and asociality, associated with the disorganization of thinking and delusional mood. The association of negative symptoms with the depressive symptom "hopelessness" reflects the contribution of depression to the formation of secondary negative symptoms. The structure of affective disorders in schizophrenia is dominated by hypothymia, hopelessness and suicidal tendencies. In patients with dominant negative symptoms, depression is less pronounced. The presence of extrapyramidal side effects makes a significant contribution to the development of secondary negative symptoms, anhedonia, asociality and blunted affect, and impairs auditory-speech memory. A network analysis of symptoms was carried out with the allocation of central symptoms.

AB - The paper presents the results of a study of the severity, structure and relationships of negative, affective and cognitive disorders in 40 patients with schizophrenia as an example. A clinical scale assessment was used. In the structure of a markedly pronounced neurocognitive deficit in patients with schizophrenia, disturbances in auditory-verbal memory, executive functions, and attention predominate. Neurocognitive deficit, in particular, the deterioration of executive functions, increases with the duration of the disease. Negative symptoms are moderately expressed with the dominance of anhedonia and asociality, associated with the disorganization of thinking and delusional mood. The association of negative symptoms with the depressive symptom "hopelessness" reflects the contribution of depression to the formation of secondary negative symptoms. The structure of affective disorders in schizophrenia is dominated by hypothymia, hopelessness and suicidal tendencies. In patients with dominant negative symptoms, depression is less pronounced. The presence of extrapyramidal side effects makes a significant contribution to the development of secondary negative symptoms, anhedonia, asociality and blunted affect, and impairs auditory-speech memory. A network analysis of symptoms was carried out with the allocation of central symptoms.

KW - cognitive deficit

KW - depression

KW - negative symptoms

KW - schizophrenia

UR - https://www.mendeley.com/catalogue/f2801f34-2609-3606-afbc-3363190bca4a/

U2 - 10.34883/PI.2023.14.2.008

DO - 10.34883/PI.2023.14.2.008

M3 - статья

VL - 14

SP - 123

EP - 131

JO - Psychiatry, Psychotherapy and Clinical Psychology

JF - Psychiatry, Psychotherapy and Clinical Psychology

SN - 2220-1122

IS - 2

ER -