TY - JOUR

T1 - Потенциальная роль лактоферрина для ранней диагностики и лечения болезни Паркинсона.

AU - Sokolov, A.V.

AU - Miliukhina, I.V.

AU - Belsky, Y.P.

AU - Vasilyev, V.B.

PY - 2020

Y1 - 2020

N2 - Incidence of Parkinson disease progressively grows with increasing age and percentage of elderly people in the global population. Clear understanding of the causes of dopaminergic neurons' death in Substantia nigra and Parkinson disease pathogenesis are currently absent, not speaking of an efficient therapy. However, an early diagnosis of dopaminergic neurons' degeneration and prescription of dopamine replacement therapy significantly slow down the rate of symptoms' progression. An increased concentration of iron in Substantia nigra of Parkinson disease patients has been shown in several studies. In this review we summarized the data concerning a potential significance of lactoferrin, the iron-binding protein of exocrine secretions and neutrophils, for early diagnosis and treatment of Parkinson disease. Salivary and lacrimal lactoferrin levels in Parkinson disease patients were higher than those observed in the control group. Plasma levels of lactoferrin inversely correlated with Parkinson disease severity ev

AB - Incidence of Parkinson disease progressively grows with increasing age and percentage of elderly people in the global population. Clear understanding of the causes of dopaminergic neurons' death in Substantia nigra and Parkinson disease pathogenesis are currently absent, not speaking of an efficient therapy. However, an early diagnosis of dopaminergic neurons' degeneration and prescription of dopamine replacement therapy significantly slow down the rate of symptoms' progression. An increased concentration of iron in Substantia nigra of Parkinson disease patients has been shown in several studies. In this review we summarized the data concerning a potential significance of lactoferrin, the iron-binding protein of exocrine secretions and neutrophils, for early diagnosis and treatment of Parkinson disease. Salivary and lacrimal lactoferrin levels in Parkinson disease patients were higher than those observed in the control group. Plasma levels of lactoferrin inversely correlated with Parkinson disease severity ev

KW - iron

KW - lactoferrin

KW - Parkinson's disease

KW - болезнь Паркинсона

KW - железо

KW - лактоферрин

KW - iron

KW - lactoferrin

KW - Parkinson's disease

KW - болезнь Паркинсона

KW - железо

KW - лактоферрин

M3 - Article

VL - 20

SP - 37

EP - 44

JO - Medicinskij Akademiceskij Zurnal

JF - Medicinskij Akademiceskij Zurnal

SN - 1608-4101

IS - 1

ER -