РОЛЬ МИКРОБИОТЫ ЖЕЛУДОЧНО-КИШЕЧНОГО ТРАКТА В РАЗВИТИИ ГЕСТАЦИОННОГО САХАРНОГО ДИАБЕТА

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РОЛЬ МИКРОБИОТЫ ЖЕЛУДОЧНО-КИШЕЧНОГО ТРАКТА В РАЗВИТИИ ГЕСТАЦИОННОГО САХАРНОГО ДИАБЕТА. / Оноприйчук, Александра Романовна ; Капустин, Роман Викторович ; Аржанова, Ольга Николаевна.

в: Akusherstvo i Ginekologiya (Russian Federation), Том 2020, № 3, 2020, стр. 18-24.

Результаты исследований: Научные публикации в периодических изданиях › Обзорная статья › Рецензирование

BibTeX

@article{fc1104becf4c4077aaf5280ab0e9e731,

title = "РОЛЬ МИКРОБИОТЫ ЖЕЛУДОЧНО-КИШЕЧНОГО ТРАКТА В РАЗВИТИИ ГЕСТАЦИОННОГО САХАРНОГО ДИАБЕТА",

abstract = "Gut microbiota regulates many processes occurring in the intestine, affecting its immune and endocrine functions, the absorption of substances. There is a hypothesis that intestinal dysbiosis plays a role in the pathogenesis of gestational diabetes mellitus (GDM). The paper reviews the data available in the literature of the world{\textquoteright}s leading reference bases (MEDLINE, EMBASE, Cochrane) on changes in the microbiota and microbiome in women with GDM. An analysis of the findings has revealed numerous correlations between specific bacterial taxa and changes in the metabolic process in the body during pregnancy. The possible mechanism for the development of GDM is the occurrence of inflammation in the intestinal wall in the presence of gut dysbiosis, which results in barrier dysfunction of enterocytes and in an increase in their permeability and endotoxemia. This leads to overexpression of proinflammatory cytokines and increased insulin resistance. The use of probiotics is a method to correct gut dysbiosis. The administration of probiotics is shown to reduce subclinical inflammatory responses and to restore the balance of absorbed substances. It is probable that this method may also be relevant to the therapy of hyperglycemic states during pregnancy.",

keywords = "МИКРОБИОТА, МИКРОБИОМ, МИКРОФЛОРА, ГЕСТАЦИОННЫЙ САХАРНЫЙ ДИАБЕТ, ИНСУЛИНОРЕЗИСТЕНТНОСТЬ, ГИПЕРГЛИКЕМИЯ, ПРОБИОТИКИ, MICROBIOTA, MICROBIOME, MICROFLORA, GESTATIONAL DIABETES MELLITUS, INSULIN RESISTANCE, HYPERGLYCEMIA, PROBIOTICS",

author = "Оноприйчук, {Александра Романовна} and Капустин, {Роман Викторович} and Аржанова, {Ольга Николаевна}",

year = "2020",

doi = "10.18565/aig.2020.3.18-24",

language = "русский",

volume = "2020",

pages = "18--24",

journal = "Akusherstvo i Ginekologiya (Bulgaria)",

issn = "0300-9092",

publisher = "Бионика Медиа",

number = "3",

}

RIS

TY - JOUR

T1 - РОЛЬ МИКРОБИОТЫ ЖЕЛУДОЧНО-КИШЕЧНОГО ТРАКТА В РАЗВИТИИ ГЕСТАЦИОННОГО САХАРНОГО ДИАБЕТА

AU - Оноприйчук, Александра Романовна

AU - Капустин, Роман Викторович

AU - Аржанова, Ольга Николаевна

PY - 2020

Y1 - 2020

N2 - Gut microbiota regulates many processes occurring in the intestine, affecting its immune and endocrine functions, the absorption of substances. There is a hypothesis that intestinal dysbiosis plays a role in the pathogenesis of gestational diabetes mellitus (GDM). The paper reviews the data available in the literature of the world’s leading reference bases (MEDLINE, EMBASE, Cochrane) on changes in the microbiota and microbiome in women with GDM. An analysis of the findings has revealed numerous correlations between specific bacterial taxa and changes in the metabolic process in the body during pregnancy. The possible mechanism for the development of GDM is the occurrence of inflammation in the intestinal wall in the presence of gut dysbiosis, which results in barrier dysfunction of enterocytes and in an increase in their permeability and endotoxemia. This leads to overexpression of proinflammatory cytokines and increased insulin resistance. The use of probiotics is a method to correct gut dysbiosis. The administration of probiotics is shown to reduce subclinical inflammatory responses and to restore the balance of absorbed substances. It is probable that this method may also be relevant to the therapy of hyperglycemic states during pregnancy.

AB - Gut microbiota regulates many processes occurring in the intestine, affecting its immune and endocrine functions, the absorption of substances. There is a hypothesis that intestinal dysbiosis plays a role in the pathogenesis of gestational diabetes mellitus (GDM). The paper reviews the data available in the literature of the world’s leading reference bases (MEDLINE, EMBASE, Cochrane) on changes in the microbiota and microbiome in women with GDM. An analysis of the findings has revealed numerous correlations between specific bacterial taxa and changes in the metabolic process in the body during pregnancy. The possible mechanism for the development of GDM is the occurrence of inflammation in the intestinal wall in the presence of gut dysbiosis, which results in barrier dysfunction of enterocytes and in an increase in their permeability and endotoxemia. This leads to overexpression of proinflammatory cytokines and increased insulin resistance. The use of probiotics is a method to correct gut dysbiosis. The administration of probiotics is shown to reduce subclinical inflammatory responses and to restore the balance of absorbed substances. It is probable that this method may also be relevant to the therapy of hyperglycemic states during pregnancy.

KW - МИКРОБИОТА

KW - МИКРОБИОМ

KW - МИКРОФЛОРА

KW - ГЕСТАЦИОННЫЙ САХАРНЫЙ ДИАБЕТ

KW - ИНСУЛИНОРЕЗИСТЕНТНОСТЬ

KW - ГИПЕРГЛИКЕМИЯ

KW - ПРОБИОТИКИ

KW - MICROBIOTA

KW - MICROBIOME

KW - MICROFLORA

KW - GESTATIONAL DIABETES MELLITUS

KW - INSULIN RESISTANCE

KW - HYPERGLYCEMIA

KW - PROBIOTICS

UR - http://www.scopus.com/inward/record.url?scp=85085161897&partnerID=8YFLogxK

U2 - 10.18565/aig.2020.3.18-24

DO - 10.18565/aig.2020.3.18-24

M3 - Обзорная статья

AN - SCOPUS:85085161897

VL - 2020

SP - 18

EP - 24

JO - Akusherstvo i Ginekologiya (Bulgaria)

JF - Akusherstvo i Ginekologiya (Bulgaria)

SN - 0300-9092

IS - 3

ER -

ID: 85957100