Hydroponic technologies have significant, poorly implemented resource for developing science-based techniques of effects on the processes of growth, biomass formation and chemical composition of plants. Here we consider the effectiveness of some approaches to the optimization of mineral nutrition in ontogenesis of plants in conditions of ”forced” and “selective” systems of plant nutrition to manage the formation of yield and biochemical composition of plant production. Special attention is paid to methods of plant growth inhibition, of nutrient solutions modification and of nitrate and oxalate levels their regulation in plants under hydroponic culture. The results convincingly show that optimization of root nutrition at different stages of plants ontogenesis through surgical correction of solution composition and mode of feeding plants is essential for the formation of biomass and yield quality in the conditions of hydroponic culture. It is concluded that temporary exclusion of nitrate nitrogen from the nu