TY - JOUR

T1 - Роль микробиома кишечника и амилоидов бактерий в развитии синуклеинопатий

AU - Трубицина, Нина Павловна

AU - Матиив, Антон Богданович

AU - Рогоза, Татьяна Михайловна

AU - Зудилова, Анна Алексеевна

AU - Безгина, Мария Дмитриевна

AU - Журавлева, Галина Анатольевна

AU - Бондарев, Станислав Александрович

PY - 2024/4/8

Y1 - 2024/4/8

N2 - Less than ten years ago, evidence began to accumulate about association between the changes in the composition of gut microbiota and development of human synucleinopathies, in particular sporadic form of Parkinson's disease. We collected data from more than one hundred and thirty experimental studies that reported similar results and summarized the frequencies of detection of different groups of bacteria in these studies. It is important to note that it is extremely rare that a unidirectional change in the population of one or another group of microorganisms (only an elevation or only a reduction) was detected in the patients with Parkinson's disease. However, we were able to identify several groups of bacteria that were overrepresented in the patients with Parkinson's disease in the analyzed studies. There are various hypotheses about the molecular mechanisms that explain such relationships. Usually, α-synuclein aggregation is associated with the development of inflammatory processes that occur in response to the changes in the microbiome. However, experimental evidence is accumulating on the influence of bacterial proteins, including amyloids (curli), as well as various metabolites, on the α-synuclein aggregation. In the review, we provided up-to-date information about such examples.

AB - Less than ten years ago, evidence began to accumulate about association between the changes in the composition of gut microbiota and development of human synucleinopathies, in particular sporadic form of Parkinson's disease. We collected data from more than one hundred and thirty experimental studies that reported similar results and summarized the frequencies of detection of different groups of bacteria in these studies. It is important to note that it is extremely rare that a unidirectional change in the population of one or another group of microorganisms (only an elevation or only a reduction) was detected in the patients with Parkinson's disease. However, we were able to identify several groups of bacteria that were overrepresented in the patients with Parkinson's disease in the analyzed studies. There are various hypotheses about the molecular mechanisms that explain such relationships. Usually, α-synuclein aggregation is associated with the development of inflammatory processes that occur in response to the changes in the microbiome. However, experimental evidence is accumulating on the influence of bacterial proteins, including amyloids (curli), as well as various metabolites, on the α-synuclein aggregation. In the review, we provided up-to-date information about such examples.

KW - амилоиды

KW - альфа-синуклеин

KW - болезнь Паркинсона

KW - микробиом

KW - нейродегенеративные заболевания

UR - https://www.mendeley.com/catalogue/541d28e5-de39-3457-962f-91930f704fea/

U2 - 10.1134/s0006297924030118

DO - 10.1134/s0006297924030118

M3 - статья

VL - 89

SP - 523

EP - 542

JO - БИОХИМИЯ

JF - БИОХИМИЯ

SN - 0320-9725

IS - 3

ER -