Влияние хромонсодержащих производных аллилморфолина на стресс-индуцированную гипертермию у крыс

Standard

Влияние хромонсодержащих производных аллилморфолина на стресс-индуцированную гипертермию у крыс. / Курмазов, Никита Сергеевич; Пучик, Мария Михайловна; Шиц, Дарья Дмитриевна ; Сысоев, Юрий Игоревич ; Оковитый, Сергей Владимирович.

в: БИОМЕДИЦИНА, Том 21, № 3, 19.10.2025, стр. 103-106.

Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование

BibTeX

@article{168842544ef04854af2e14d066cdfe41,

title = "Влияние хромонсодержащих производных аллилморфолина на стресс-индуцированную гипертермию у крыс",

abstract = "In this study, we evaluated the ability of three new chromone-containing allylmorpholines (33a, 33b, and 9a) to exhibit hypothermic effects in rats after a single injection. The temperature was measured rectally before the injection and after 20, 40, and 60 min. It was found that compound 33a at doses of 50, 100, and 150 mg/kg, as well as compound 33b at a dose of 60 mg/kg, were able to decrease body temperature in rats relative to the control group at the same time point. No such effects were detected with compound 9a. These data may indicate the presence of antipsychotic action of compounds 33a and 33b.",

author = "Курмазов, {Никита Сергеевич} and Пучик, {Мария Михайловна} and Шиц, {Дарья Дмитриевна} and Сысоев, {Юрий Игоревич} and Оковитый, {Сергей Владимирович}",

note = "Курмазов Н.С., Пучик М.М., Шиц Д.Д., Сысоев Ю.И., Оковитый С.В. Влияние хромонсодержащих производных аллилморфолина на стресс-индуцированную гипертермию у крыс. БИОМЕДИЦИНА. 2025;21(3):103-106. https://doi.org/10.33647/2074-5982-21-3-103-106",

year = "2025",

month = oct,

day = "19",

doi = "10.33647/2074-5982-21-3-103-106",

language = "русский",

volume = "21",

pages = "103--106",

journal = "БИОМЕДИЦИНА",

issn = "2074-5982",

publisher = "Научный центр биомедицинских технологий Федерального медико-биологического агентства",

number = "3",

}

RIS

TY - JOUR

T1 - Влияние хромонсодержащих производных аллилморфолина на стресс-индуцированную гипертермию у крыс

AU - Курмазов, Никита Сергеевич

AU - Пучик, Мария Михайловна

AU - Шиц, Дарья Дмитриевна

AU - Сысоев, Юрий Игоревич

AU - Оковитый, Сергей Владимирович

N1 - Курмазов Н.С., Пучик М.М., Шиц Д.Д., Сысоев Ю.И., Оковитый С.В. Влияние хромонсодержащих производных аллилморфолина на стресс-индуцированную гипертермию у крыс. БИОМЕДИЦИНА. 2025;21(3):103-106. https://doi.org/10.33647/2074-5982-21-3-103-106

PY - 2025/10/19

Y1 - 2025/10/19

N2 - In this study, we evaluated the ability of three new chromone-containing allylmorpholines (33a, 33b, and 9a) to exhibit hypothermic effects in rats after a single injection. The temperature was measured rectally before the injection and after 20, 40, and 60 min. It was found that compound 33a at doses of 50, 100, and 150 mg/kg, as well as compound 33b at a dose of 60 mg/kg, were able to decrease body temperature in rats relative to the control group at the same time point. No such effects were detected with compound 9a. These data may indicate the presence of antipsychotic action of compounds 33a and 33b.

AB - In this study, we evaluated the ability of three new chromone-containing allylmorpholines (33a, 33b, and 9a) to exhibit hypothermic effects in rats after a single injection. The temperature was measured rectally before the injection and after 20, 40, and 60 min. It was found that compound 33a at doses of 50, 100, and 150 mg/kg, as well as compound 33b at a dose of 60 mg/kg, were able to decrease body temperature in rats relative to the control group at the same time point. No such effects were detected with compound 9a. These data may indicate the presence of antipsychotic action of compounds 33a and 33b.

UR - https://www.mendeley.com/catalogue/df445641-ceb9-31d0-8a88-d032f15fd046/

U2 - 10.33647/2074-5982-21-3-103-106

DO - 10.33647/2074-5982-21-3-103-106

M3 - статья

VL - 21

SP - 103

EP - 106

JO - БИОМЕДИЦИНА

JF - БИОМЕДИЦИНА

SN - 2074-5982

IS - 3

ER -

ID: 142797785