Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
Ренальная дисфункция как осложнение острого повреждения головного мозга. / Basantsova, N. Yu; Shishkin, A. N.; Tibekina, L. M.; Erman, M. V.; Volovnikova, V. A.; Tyapkina, V. S.
в: Arterial Hypertension (Russian Federation), Том 25, № 6, 2019, стр. 674-681.Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
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TY - JOUR
T1 - Ренальная дисфункция как осложнение острого повреждения головного мозга
AU - Basantsova, N. Yu
AU - Shishkin, A. N.
AU - Tibekina, L. M.
AU - Erman, M. V.
AU - Volovnikova, V. A.
AU - Tyapkina, V. S.
N1 - Publisher Copyright: © 2019 All-Russian Public Organization Antihypertensive League. All rights reserved. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2019
Y1 - 2019
N2 - The development of internal disease as a result of the brain damage was first described more than one hundred years ago, but the role of acute stroke and traumatic brain injury (TBI) in the progression of renal dysfunction has not been studied enough. Within the first 7 days after onset of subarachnoid hemorrhage or TBI, up to 25 % patients develop acute kidney injury (AKI). Other important manifestations of cerebro-renal disorders include central salt-wasting syndrome and syndrome of inappropriate antidiuretic hormone secretion, that both manifest by hyponatremia, but differ in pathogenesis and clinical tactics. In addition, patients with extensive brain lesions are characterized by excessive sympathetic activation with the release of proinflammatory cytokines, such as tumor necrosis factor α (TNFα), interleukin-6 (IL-6) and interferon γ (IFNγ), which also contributes to the development of AKI. Investigation of the main features of cerebro-renal syndrome will contribute to the early diagnostics, choice of the appropriate management strategy (careful and limited use of nephrotoxic antimicrobial drugs, osmotic diuretics and intravenous contrasting in neuroimaging) and to the improvement of the prognosis.
AB - The development of internal disease as a result of the brain damage was first described more than one hundred years ago, but the role of acute stroke and traumatic brain injury (TBI) in the progression of renal dysfunction has not been studied enough. Within the first 7 days after onset of subarachnoid hemorrhage or TBI, up to 25 % patients develop acute kidney injury (AKI). Other important manifestations of cerebro-renal disorders include central salt-wasting syndrome and syndrome of inappropriate antidiuretic hormone secretion, that both manifest by hyponatremia, but differ in pathogenesis and clinical tactics. In addition, patients with extensive brain lesions are characterized by excessive sympathetic activation with the release of proinflammatory cytokines, such as tumor necrosis factor α (TNFα), interleukin-6 (IL-6) and interferon γ (IFNγ), which also contributes to the development of AKI. Investigation of the main features of cerebro-renal syndrome will contribute to the early diagnostics, choice of the appropriate management strategy (careful and limited use of nephrotoxic antimicrobial drugs, osmotic diuretics and intravenous contrasting in neuroimaging) and to the improvement of the prognosis.
KW - Acute kidney injury
KW - Central salt-wasting syndrome
KW - Renal dysfunction
KW - Stroke
KW - Syndrome of inappropriate antidiuretic hormone secretion
KW - Trauma brain injury
UR - http://www.scopus.com/inward/record.url?scp=85086243481&partnerID=8YFLogxK
U2 - 10.18705/1607-419X-2019-25-6-674-681
DO - 10.18705/1607-419X-2019-25-6-674-681
M3 - статья
AN - SCOPUS:85086243481
VL - 25
SP - 674
EP - 681
JO - Arterial Hypertension (Russian Federation)
JF - Arterial Hypertension (Russian Federation)
SN - 1607-419X
IS - 6
ER -
ID: 39775626