TY - JOUR

T1 - Механизмы реализации синдрома ишемии-реперфузии при чрескожном коронарном вмешательстве

T2 - (аналитический обзор)

AU - Семиголовский, Никита Юрьевич

AU - Симутис, Ионас Стасио

AU - Лобаченко, И.Г.

AU - Данилов, М.С.

AU - Юсупов , Э.С.

AU - Суворова, Юлия Владимировна

AU - Сапегин, А.А.

AU - Лыточкина, С.В.

AU - Яковлев, А.Ю.

PY - 2025/10/22

Y1 - 2025/10/22

N2 - Introduction. Despite the known risks of myocardial damage as a result of reperfusion, current treatment strategies often focus only on immediate recanalization of the coronary arteries. At the same time, a lot of experimental and clinical data confirms that this procedure can provoke additional ischemic reperfusion injury to the myocardium. Objective. Analysis of the existing literature on ischemia-reperfusion syndrome in percutaneous coronary intervention in order to systematize knowledge about the mechanisms of its development. Material and methods. The study was conducted in collaboration with international organizations to analyze PRISMA (Preferred Reporting Articles for Systematic Reviews and Meta-analyses). The search for users was conducted in the PubMed, Google Scholar, and eLibrary.ru. Results. A total of 4,268 initial results were found, including PubMed — 2,134 publications, Google Scholar — 1,280 and eLibrary. ru — 854 publication. Only 1,523 papers turned out to be relevant, after studying which only 70 full-text publications were selected for the review, which met all the selection criteria and were included in the analysis. Most studies describe the pathophysiological mechanisms contributing to the development of ischemia-reperfusion syndrome during percutaneous coronary intervention. Conclusion. Ischemia-reperfusion syndrome causes activation of various pathophysiological mechanisms, among which endothelial dysfunction, oxidative stress, inflammatory response, and energy exchange disorders play a leading role. This is the basis for the development of new therapeutic strategies to prevent myocardial damage during percutaneous coronary interventions and improve treatment outcomes in patients with coronary artery disease.

AB - Introduction. Despite the known risks of myocardial damage as a result of reperfusion, current treatment strategies often focus only on immediate recanalization of the coronary arteries. At the same time, a lot of experimental and clinical data confirms that this procedure can provoke additional ischemic reperfusion injury to the myocardium. Objective. Analysis of the existing literature on ischemia-reperfusion syndrome in percutaneous coronary intervention in order to systematize knowledge about the mechanisms of its development. Material and methods. The study was conducted in collaboration with international organizations to analyze PRISMA (Preferred Reporting Articles for Systematic Reviews and Meta-analyses). The search for users was conducted in the PubMed, Google Scholar, and eLibrary.ru. Results. A total of 4,268 initial results were found, including PubMed — 2,134 publications, Google Scholar — 1,280 and eLibrary. ru — 854 publication. Only 1,523 papers turned out to be relevant, after studying which only 70 full-text publications were selected for the review, which met all the selection criteria and were included in the analysis. Most studies describe the pathophysiological mechanisms contributing to the development of ischemia-reperfusion syndrome during percutaneous coronary intervention. Conclusion. Ischemia-reperfusion syndrome causes activation of various pathophysiological mechanisms, among which endothelial dysfunction, oxidative stress, inflammatory response, and energy exchange disorders play a leading role. This is the basis for the development of new therapeutic strategies to prevent myocardial damage during percutaneous coronary interventions and improve treatment outcomes in patients with coronary artery disease.

KW - синдром ишемии-реперфузии

KW - ЧКВ

KW - ischemia-reperfusion syndrome

KW - pathogenesis

KW - pathophysiology

KW - percutaneous coronary intervention

UR - https://www.mendeley.com/catalogue/5d98299e-53b1-3bdc-9a1e-1da3ebfe68ed/

U2 - 10.17116/anaesthesiology202505188

DO - 10.17116/anaesthesiology202505188

M3 - статья

SP - 88

EP - 97

JO - Russian Journal of Anesthesiology and Reanimatology /Anesteziologiya i Reanimatologiya

JF - Russian Journal of Anesthesiology and Reanimatology /Anesteziologiya i Reanimatologiya

SN - 0201-7563

IS - 5

ER -