Purpose of the study is to perform first line Giotrif® (afatinib) health economic assessment in patients with metastatic NSCLC with EGFR mutations. Markov model and budget impact model were implemented to simulate afatinib monotherapy in treatment of naïve patients versus one of the chemotherapy combinations cisplatin/pemetrexed or cisplatin/docetaxel based on randomized clinical trial results data as inputs. Afatinib was shown to be cost-effective strategy.