Taking into account widespread use of check-point inhibitors in real clinical practice, pharmacoeconomic issues, the incidence and grade of immune-related adverse events, there is an urgent need for using prognostic and predictive biomarkers of toxicity of immunotherapy. This review presents a literature review of the databases such as PubMed, MEDLINE, Google Scholar, Springer. Articles were searched using the keywords: «predictive biomarkers of toxicity», «immunotherapy», «predictive markers of immune-related adverse events». Subsequently the information obtained was analyzed in order to define possible predictive biomarkers of immune-related toxicity that could be used in real clinical practice.