Digitalization, as the most important trend in the modern development of the economy and society, can be accompanied by not only positive but also negative consequences. In order for it to have only a positive impact, it is necessary to fulfill the requirements that it presents to society in the form of the content of the challenges. In the case when these requirements are not met, there is a threat of negative consequences of the impact of digitalization, which are proposed to be described through risk. The article proposes to solve the problem of enhancing the positive and reducing the negative impact of digitalization on the activities of a certain subject and/or on the content of any object impacted by digitalization on the basis of the creation and implementation of a Comprehensive Digitalization Risk Management Program. It includes Program N 1 for managing risks caused by the impact of digitalization on a certain area of society; Program N 2 for managing risks caused by the use of main digitalization products; Cyber Risk Management Program N 3 or Information Risk Management Program N 4, of which Program N 3 is a part. Each of these programs contains 2 parts: part 1 contains management decisions developed independently, part 2 contains management decisions to implement the requirements of regulatory legal acts, as well as national and interstate standards that implement risk management of information security violations at the state, interstate or industry levels level.