Relevance. Currently, there is no universally recognized standard method for diagnosis of sepsis in patients with burn injury, which causes many variations when recording septic conditions and also high mortality of such patients. Traditionally, patients in intensive care units are assessed using the clinical scales SOFA, APACHE II-IV or SAPS II-III. However, most of the known clinical scales cannot always be used to assess the severity of burn injuries. Therefore, unrecognized sepsis can lead to the multiple organ dysfunction syndrome that is the main cause of death in burn patients. The definition, systematization and standardization of new criteria for sepsis and predictors of its development can significantly improve the medical care for patients in this category and reduce the level of mortality. Intention. To review the studies of burn sepsis biomarkers using publications from the National Center for Biotechnological Information and the Scientific Electronic Library (eLIBRARY) over 2003–2017. Methodology. This article provides an overview of the most promising clinical and laboratory markers of sepsis with high predictive and diagnostic value that can be used to predict and assess the severity of burn injuries. Results and their analysis. Over the past 15 years, many potential biomarkers of burn sepsis have been studied. The most promising of them are: tumor necrosis factor-alpha, interleukin-6, interleukin-8, interleukin-10, interleukin-27, presepsin, endotoxin of gram-positive bacteria, lipopolysaccharide-binding protein, soluble receptor of urokinase-type plasminogen activator, trigger receptor expressed on myeloid cells, and myeloperoxidase. The most topical current method for laboratory diagnostics of these biomarkers can be the enzyme-linked immunoassay in the biochip format. Сonclusion. Integrated and simultaneous measurements of the sepsis markers reviewed in this article within one study can be useful for diagnosing sepsis in severely burned patients in the future.