Research output: Contribution to journal › Review article › peer-review
Zebrafish models of diabetes-related CNS pathogenesis. / Lakstygal, Anton M.; de Abreu, Murilo S.; Lifanov, Dmitry A.; Wappler-Guzzetta, Edina A.; Serikuly, Nazar; Alpsyshov, Erik T.; Wang, Dong Mei; Wang, Meng Yao; Tang, Zhi Chong; Yan, Dong Ni; Demin, Konstantin A.; Volgin, Andrey D.; Amstislavskaya, Tamara G.; Wang, Jia Jia; Song, Cai; Alekseeva, Polina; Kalueff, Allan V.
In: Progress in Neuro-Psychopharmacology and Biological Psychiatry, Vol. 92, 08.06.2019, p. 48-58.Research output: Contribution to journal › Review article › peer-review
}
TY - JOUR
T1 - Zebrafish models of diabetes-related CNS pathogenesis
AU - Lakstygal, Anton M.
AU - de Abreu, Murilo S.
AU - Lifanov, Dmitry A.
AU - Wappler-Guzzetta, Edina A.
AU - Serikuly, Nazar
AU - Alpsyshov, Erik T.
AU - Wang, Dong Mei
AU - Wang, Meng Yao
AU - Tang, Zhi Chong
AU - Yan, Dong Ni
AU - Demin, Konstantin A.
AU - Volgin, Andrey D.
AU - Amstislavskaya, Tamara G.
AU - Wang, Jia Jia
AU - Song, Cai
AU - Alekseeva, Polina
AU - Kalueff, Allan V.
PY - 2019/6/8
Y1 - 2019/6/8
N2 - Diabetes mellitus (DM) is a common metabolic disorder that affects multiple organ systems. DM also affects brain processes, contributing to various CNS disorders, including depression, anxiety and Alzheimer's disease. Despite active research in humans, rodent models and in-vitro systems, the pathogenetic link between DM and brain disorders remains poorly understood. Novel translational models and new model organisms are therefore essential to more fully study the impact of DM on CNS. The zebrafish (Danio rerio) is a powerful novel model species to study metabolic and CNS disorders. Here, we discuss how DM alters brain functions and behavior in zebrafish, and summarize their translational relevance to studying DM-related CNS pathogenesis in humans. We recognize the growing utility of zebrafish models in translational DM research, as they continue to improve our understanding of different brain pathologies associated with DM, and may foster the discovery of drugs that prevent or treat these diseases.
AB - Diabetes mellitus (DM) is a common metabolic disorder that affects multiple organ systems. DM also affects brain processes, contributing to various CNS disorders, including depression, anxiety and Alzheimer's disease. Despite active research in humans, rodent models and in-vitro systems, the pathogenetic link between DM and brain disorders remains poorly understood. Novel translational models and new model organisms are therefore essential to more fully study the impact of DM on CNS. The zebrafish (Danio rerio) is a powerful novel model species to study metabolic and CNS disorders. Here, we discuss how DM alters brain functions and behavior in zebrafish, and summarize their translational relevance to studying DM-related CNS pathogenesis in humans. We recognize the growing utility of zebrafish models in translational DM research, as they continue to improve our understanding of different brain pathologies associated with DM, and may foster the discovery of drugs that prevent or treat these diseases.
KW - Behavior
KW - CNS
KW - Diabetes
KW - Glucose
KW - Zebrafish
KW - Diabetes Mellitus/drug therapy
KW - Animals
KW - Behavior, Animal/physiology
KW - Humans
KW - Brain/physiopathology
KW - Central Nervous System Diseases/drug therapy
KW - Disease Models, Animal
UR - http://www.scopus.com/inward/record.url?scp=85059351774&partnerID=8YFLogxK
UR - http://www.mendeley.com/research/zebrafish-models-diabetesrelated-cns-pathogenesis
U2 - 10.1016/j.pnpbp.2018.11.016
DO - 10.1016/j.pnpbp.2018.11.016
M3 - Review article
C2 - 30476525
AN - SCOPUS:85059351774
VL - 92
SP - 48
EP - 58
JO - Progress in Neuro-Psychopharmacology and Biological Psychiatry
JF - Progress in Neuro-Psychopharmacology and Biological Psychiatry
SN - 0278-5846
ER -
ID: 45075458