Zebrafish models for translational neuroscience research : From tank to bedside. / Stewart, Adam Michael; Braubach, Oliver; Spitsbergen, Jan; Gerlai, Robert; Kalueff, Allan V.
In: Trends in Neurosciences, Vol. 37, No. 5, 05.2014, p. 264-278.Research output: Contribution to journal › Review article › peer-review
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TY - JOUR
T1 - Zebrafish models for translational neuroscience research
T2 - From tank to bedside
AU - Stewart, Adam Michael
AU - Braubach, Oliver
AU - Spitsbergen, Jan
AU - Gerlai, Robert
AU - Kalueff, Allan V.
N1 - Funding Information: The authors thank Dr Jeremy Ullmann (University of Queensland, Australia), as well as Dr Lucas Noldus, Ruud Tegelenbosch and colleagues (Noldus IT, The Netherlands) for supplying images for Figures 2A and 3A, and D of this paper, and assistance in addressing reviewer's comments. The authors acknowledge the Croll and Fine laboratories (Dalhousie University, Canada) for providing the brain images for Figure 2B and C , and Mr Michael Nguyen for his assistance with this manuscript. We also thank members of the Kalueff (ZENEREI Institute, USA) and the Spitsbergen (Oregon State University, USA) laboratories for collecting samples and images used in this study. This research is supported by the National Institutes of Health/National Institute on Drug Abuse (NIH/NIDA) (A.V.K.), as well as by the NIH/National Institute on Alcohol Abuse and Alcoholism (NIAAA) and the Natural Sciences and Engineering Research Council of Canada (NSERC) (R.G.).
PY - 2014/5
Y1 - 2014/5
N2 - The zebrafish (Danio rerio) is emerging as a new important species for studying mechanisms of brain function and dysfunction. Focusing on selected central nervous system (CNS) disorders (brain cancer, epilepsy, and anxiety) and using them as examples, we discuss the value of zebrafish models in translational neuroscience. We further evaluate the contribution of zebrafish to neuroimaging, circuit level, and drug discovery research. Outlining the role of zebrafish in modeling a wide range of human brain disorders, we also summarize recent applications and existing challenges in this field. Finally, we emphasize the potential of zebrafish models in behavioral phenomics and high-throughput genetic/small molecule screening, which is critical for CNS drug discovery and identifying novel candidate genes.
AB - The zebrafish (Danio rerio) is emerging as a new important species for studying mechanisms of brain function and dysfunction. Focusing on selected central nervous system (CNS) disorders (brain cancer, epilepsy, and anxiety) and using them as examples, we discuss the value of zebrafish models in translational neuroscience. We further evaluate the contribution of zebrafish to neuroimaging, circuit level, and drug discovery research. Outlining the role of zebrafish in modeling a wide range of human brain disorders, we also summarize recent applications and existing challenges in this field. Finally, we emphasize the potential of zebrafish models in behavioral phenomics and high-throughput genetic/small molecule screening, which is critical for CNS drug discovery and identifying novel candidate genes.
KW - Anxiety
KW - Biomarkers
KW - Brain disorders
KW - Cancer
KW - Epilepsy
KW - Zebrafish
UR - http://www.scopus.com/inward/record.url?scp=84899909435&partnerID=8YFLogxK
U2 - 10.1016/j.tins.2014.02.011
DO - 10.1016/j.tins.2014.02.011
M3 - Review article
C2 - 24726051
AN - SCOPUS:84899909435
VL - 37
SP - 264
EP - 278
JO - Trends in Neurosciences
JF - Trends in Neurosciences
SN - 0378-5912
IS - 5
ER -
ID: 97787947