TY - JOUR

T1 - Zebrafish models for personalized psychiatry

T2 - Insights from individual, strain and sex differences, and modeling gene x environment interactions

AU - Volgin, Andrey D.

AU - Yakovlev, Oleg A.

AU - Demin, Konstantin A.

AU - de Abreu, Murilo S.

AU - Alekseeva, Polina A.

AU - Friend, Ashton J.

AU - Lakstygal, Anton M.

AU - Amstislavskaya, Tamara G.

AU - Bao, Wandong

AU - Song, Cai

AU - Kalueff, Allan V.

N1 - Funding Information: Research (RFBR) grant 16‐04‐00851 to AVK. KAD research is sup‐ ported by the RFBR grant 18‐34‐00996. This research was presented at the “Personalized Psychiatry” symposium of the Russian Association of Psychiatrists (Chair. Prof. N.N. Petrova) during the 25th International Stress and Behavior Society (ISBS) Conference, May 18, 2018, St. Petersburg, Russia (www.stress‐and‐behavior.com). The authors thank Adil Beckozhin, Erik Alpyshov, Nazar Bekov, Dongni Yan, Zhichong Tang, and Mengyao Wang for their help with this manuscript preparation. Funding Information: The research was supported by the Russian Foundation for Basic Research (RFBR) grant 16‐04‐00851 to AVK. KAD research is supported by the RFBR grant 18–34‐00996. Publisher Copyright: © 2018 Wiley Periodicals, Inc Copyright: Copyright 2019 Elsevier B.V., All rights reserved.

PY - 2019/4

Y1 - 2019/4

N2 - Currently becoming widely recognized, personalized psychiatry focuses on unique physiological and genetic profiles of patients to best tailor their therapy. However, the role of individual differences, as well as genetic and environmental factors, in human psychiatric disorders remains poorly understood. Animal experimental models are a valuable tool to improve our understanding of disease pathophysiology and its molecular mechanisms. Due to high reproduction capability, fully sequenced genome, easy gene editing, and high genetic and physiological homology with humans, zebrafish (Danio rerio) are emerging as a novel powerful model in biomedicine. Mounting evidence supports zebrafish as a useful model organism in CNS research. Robustly expressed in these fish, individual, strain, and sex differences shape their CNS responses to genetic, environmental, and pharmacological manipulations. Here, we discuss zebrafish as a promising complementary translational tool to further advance patient-centered personalized psychiatry.

AB - Currently becoming widely recognized, personalized psychiatry focuses on unique physiological and genetic profiles of patients to best tailor their therapy. However, the role of individual differences, as well as genetic and environmental factors, in human psychiatric disorders remains poorly understood. Animal experimental models are a valuable tool to improve our understanding of disease pathophysiology and its molecular mechanisms. Due to high reproduction capability, fully sequenced genome, easy gene editing, and high genetic and physiological homology with humans, zebrafish (Danio rerio) are emerging as a novel powerful model in biomedicine. Mounting evidence supports zebrafish as a useful model organism in CNS research. Robustly expressed in these fish, individual, strain, and sex differences shape their CNS responses to genetic, environmental, and pharmacological manipulations. Here, we discuss zebrafish as a promising complementary translational tool to further advance patient-centered personalized psychiatry.

KW - gene–environment interactions

KW - individual differences

KW - personalized psychiatry

KW - zebrafish

UR - http://www.scopus.com/inward/record.url?scp=85055044401&partnerID=8YFLogxK

U2 - 10.1002/jnr.24337

DO - 10.1002/jnr.24337

M3 - Review article

C2 - 30320468

AN - SCOPUS:85055044401

VL - 97

SP - 402

EP - 413

JO - Journal of Neuroscience Research

JF - Journal of Neuroscience Research

SN - 0360-4012

IS - 4

ER -