We report a radical strategy for direct C2-alkylation of 2H-azirines via generation of elusive 2H-azirinyl radicals. These highly reactive intermediates are accessed under mild halogen-atom transfer conditions from readily available 2-haloazirines. The resulting cyclic radicals undergo regioselective Giese-type additions to electron-deficient alkenes, retaining the azirine ring. Mechanistic studies, including spin-trapping and DFT analysis, support a free radical pathway. The adducts undergo base-promoted ring expansion to yield 6-aminopyridines, underscoring this platform's synthetic utility.
Original languageEnglish
Pages (from-to)12634-12638
Number of pages5
JournalOrganic Letters
Volume27
Issue number45
DOIs
StatePublished - 4 Nov 2025

ID: 143421381