Vliianie taurina na aktivnost' Ca, Mg-ATFazy i agretatsiiu trombotsitov cheloveka. / Almazov, V A; Gurevich, V S; Mikhaĭlova, I A; Strel'tsova, E N.
In: Byulleten Eksperimentalnoi Biologii i Meditsiny, Vol. 100, No. 10, 1985, p. 398-400.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - Vliianie taurina na aktivnost' Ca, Mg-ATFazy i agretatsiiu trombotsitov cheloveka
AU - Almazov, V A
AU - Gurevich, V S
AU - Mikhaĭlova, I A
AU - Strel'tsova, E N
PY - 1985
Y1 - 1985
N2 - Effect of taurine (25 mM) on calcium metabolism in human platelets was studied. Ca, Mg-ATPase activity is significantly increased upon addition of 25 mM of taurine to the incubation medium. The activation is absent or reduced in the presence of trifluoroperazine and beta-alanine and after preincubation of platelets with colchicine and verapamil. The rate of ADP (3.5 X 10(-6) M)-induced platelet aggregation is reduced by half upon taurine addition to platelet-rich plasma. The possible role of taurine in intracellular calcium translocation and the following alteration of platelet activity is suggested.
AB - Effect of taurine (25 mM) on calcium metabolism in human platelets was studied. Ca, Mg-ATPase activity is significantly increased upon addition of 25 mM of taurine to the incubation medium. The activation is absent or reduced in the presence of trifluoroperazine and beta-alanine and after preincubation of platelets with colchicine and verapamil. The rate of ADP (3.5 X 10(-6) M)-induced platelet aggregation is reduced by half upon taurine addition to platelet-rich plasma. The possible role of taurine in intracellular calcium translocation and the following alteration of platelet activity is suggested.
KW - Blood Platelets/drug effects
KW - Ca(2+) Mg(2+)-ATPase/metabolism
KW - Calcium-Transporting ATPases/metabolism
KW - Humans
KW - In Vitro Techniques
KW - Platelet Aggregation/drug effects
KW - Stimulation, Chemical
KW - Taurine/pharmacology
M3 - статья
C2 - 2932188
VL - 100
SP - 398
EP - 400
JO - БЮЛЛЕТЕНЬ ЭКСПЕРИМЕНТАЛЬНОЙ БИОЛОГИИ И МЕДИЦИНЫ
JF - БЮЛЛЕТЕНЬ ЭКСПЕРИМЕНТАЛЬНОЙ БИОЛОГИИ И МЕДИЦИНЫ
SN - 0365-9615
IS - 10
ER -
ID: 38737658