Research output: Contribution to journal › Article › peer-review
Visual processing and BDNF levels in first-episode schizophrenia. / Shoshina, Irina I.; Hovis, Jeffery K.; Felisberti, Fatima M.; Santos, Natanael A.; Adreeva, Anna; Butler, Pamela D.; Fernandes, Thiago P.
In: Psychiatry Research, Vol. 305, 114200, 11.2021.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - Visual processing and BDNF levels in first-episode schizophrenia
AU - Shoshina, Irina I.
AU - Hovis, Jeffery K.
AU - Felisberti, Fatima M.
AU - Santos, Natanael A.
AU - Adreeva, Anna
AU - Butler, Pamela D.
AU - Fernandes, Thiago P.
N1 - Publisher Copyright: © 2021 Elsevier B.V.
PY - 2021/11
Y1 - 2021/11
N2 - Previous studies have shown that patients diagnosed with schizophrenia (SCZ) have deficits in early visual processing, namely contrast processing. The brain-derived neurotropic factor (BDNF) is an important measure to investigate neuroplasticity in some visual functions like visual perception. In this study, we investigated the relationship between visual processing and BDNF levels in first-episode SCZ patients. Thirty-nine healthy controls and 43 first-episode SCZ patients were enrolled. Contrast sensitivity measurements were conducted using low, mid- and high spatial frequencies. First-episode SCZ patients had higher contrast sensitivity than healthy controls for all frequencies, except for the middle spatial frequency. Negative correlations were found between BDNF, contrast sensitivity and clinical variables, mostly for middle and high spatial frequencies among females. Our results provide support for (i) the association of SCZ with alterations of magno- and parvocellular pathway functioning and (ii) decreased BDNF levels in first-episode SCZ patients. This study highlights the importance of using biomarkers along with other measures to investigate visual processing in SCZ and other disorders.
AB - Previous studies have shown that patients diagnosed with schizophrenia (SCZ) have deficits in early visual processing, namely contrast processing. The brain-derived neurotropic factor (BDNF) is an important measure to investigate neuroplasticity in some visual functions like visual perception. In this study, we investigated the relationship between visual processing and BDNF levels in first-episode SCZ patients. Thirty-nine healthy controls and 43 first-episode SCZ patients were enrolled. Contrast sensitivity measurements were conducted using low, mid- and high spatial frequencies. First-episode SCZ patients had higher contrast sensitivity than healthy controls for all frequencies, except for the middle spatial frequency. Negative correlations were found between BDNF, contrast sensitivity and clinical variables, mostly for middle and high spatial frequencies among females. Our results provide support for (i) the association of SCZ with alterations of magno- and parvocellular pathway functioning and (ii) decreased BDNF levels in first-episode SCZ patients. This study highlights the importance of using biomarkers along with other measures to investigate visual processing in SCZ and other disorders.
KW - Brain-derived neurotrophic factor
KW - Contrast processing
KW - First-episode
KW - Schizophrenia
KW - Visual functions
KW - SYSTEM
KW - CONTRAST SENSITIVITY
KW - NEUROTROPHIC FACTOR
KW - SERUM
KW - PERCEPTION
KW - GENE
KW - MESSENGER-RNA
KW - FREQUENCY
KW - EXPRESSION
KW - PARALLEL
UR - http://www.scopus.com/inward/record.url?scp=85116910974&partnerID=8YFLogxK
UR - https://www.mendeley.com/catalogue/ba871995-9952-3cda-9572-38cab33cdf97/
U2 - 10.1016/j.psychres.2021.114200
DO - 10.1016/j.psychres.2021.114200
M3 - Article
C2 - 34653830
AN - SCOPUS:85116910974
VL - 305
JO - Psychiatry Research
JF - Psychiatry Research
SN - 0165-1781
M1 - 114200
ER -
ID: 86363904