Infrared fluorescence and double infrared resonance have been used to measure the V-T relaxation of CD₃F and CD₄ in mixtures with He, Ne, Ar, Kr, Xe and HCl in the gas phase and in the liquid Ar, Kr, Xe. It is shown that the temperature dependence of V-T probabilities in the interval 350-150°K can be attributed to an increasing influence of long range forces. In the mixture CD₃F + HCl, where H-bonded complexes CD₃F...HCl have been formed, the vibrational relaxation rate considerably increases with decreasing temperature. It is found that the probabilities of V-T energy transfer in cryogenic solutions are lower than those measured in the gas phae.