Introduction
We studied 80 surgical patients with renal cancer (RC). They were randomized depending on the treatment method into 2 groups: the first (n=40): patients with T3 stage of RC after surgical (open) nephrectomy, aged 50.1±3.47 years, among them there were 18 men (45.0 %), and 22 women (55.0 %); and the second (n=40), similar to the first, but after laparoscopic nephrectomy, aged 52.4±5.13 years, men 16 (40.0%), and women 24 (60.0 %).
Methods
The methods for assessing endogenous intoxication,lipid peroxidation, glomerular filtration rate, and albumin-creatinine ratio were used in the study.
Results
It was established that the initial time of the postoperative period of nephrectomy in kidney cancer is accompanied by the development of endogenous intoxication and the intensification of the processes of lipid peroxidation.
Conclusions
The use of nephrectomy in patients with kidney cancer was associated with a high risk of functional dysfunction on the one hand, and its chronic disease, on the other. It should be noted that systemic parameters, such as endotoxic manifestation (toxicity index and average mass molecules) and oxidative depression (diene conjugates and malondialdehyde), and renal parameters (glomerular filtration rate and albumin-creatinine ratio) are associated with the type of nephrectomy. In the laparoscopic nephrectomy, these changes are reversible, and the intensity is less expressed.