Research output: Contribution to journal › Review article › peer-review
Understanding taurine CNS activity using alternative zebrafish models. / Mezzomo, Nathana J.; Fontana, Barbara D.; Kalueff, Allan V.; Barcellos, Leonardo J.G.; Rosemberg, Denis B.
In: Neuroscience and Biobehavioral Reviews, Vol. 83, No. December, 12.2017, p. 525-539.Research output: Contribution to journal › Review article › peer-review
}
TY - JOUR
T1 - Understanding taurine CNS activity using alternative zebrafish models
AU - Mezzomo, Nathana J.
AU - Fontana, Barbara D.
AU - Kalueff, Allan V.
AU - Barcellos, Leonardo J.G.
AU - Rosemberg, Denis B.
N1 - Publisher Copyright: © 2017 Elsevier Ltd
PY - 2017/12
Y1 - 2017/12
N2 - Taurine is a highly abundant "amino acid" in the brain. Despite the potential neuroactive role of taurine in vertebrates has long been recognized, the underlying molecular mechanisms related to its pleiotropic effects in the brain remain poorly understood. Due to the genetic tractability, rich behavioral repertoire, neurochemical conservation, and small size, the zebrafish (Danio rerio) has emerged as a powerful candidate for neuropsychopharmacology investigation and in vivo drug screening. Here, we summarize the main physiological roles of taurine in mammals, including neuromodulation, osmoregulation, membrane stabilization, and antioxidant action. In this context, we also highlight how zebrafish models of brain disorders may present interesting approaches to assess molecular mechanisms underlying positive effects of taurine in the brain. Finally, we outline recent advances in zebrafish drug screening that significantly improve neuropsychiatric translational researches and small molecule screens.
AB - Taurine is a highly abundant "amino acid" in the brain. Despite the potential neuroactive role of taurine in vertebrates has long been recognized, the underlying molecular mechanisms related to its pleiotropic effects in the brain remain poorly understood. Due to the genetic tractability, rich behavioral repertoire, neurochemical conservation, and small size, the zebrafish (Danio rerio) has emerged as a powerful candidate for neuropsychopharmacology investigation and in vivo drug screening. Here, we summarize the main physiological roles of taurine in mammals, including neuromodulation, osmoregulation, membrane stabilization, and antioxidant action. In this context, we also highlight how zebrafish models of brain disorders may present interesting approaches to assess molecular mechanisms underlying positive effects of taurine in the brain. Finally, we outline recent advances in zebrafish drug screening that significantly improve neuropsychiatric translational researches and small molecule screens.
KW - Brain disorder
KW - Neural function
KW - Neuropsychopharmacology
KW - Taurine
KW - Zebrafish
KW - DANIO-RERIO
KW - OXIDATIVE STRESS
KW - ALZHEIMERS-DISEASE
KW - SULFINIC ACID DECARBOXYLASE
KW - NEGATIVE FEEDBACK SENSITIVITY
KW - CENTRAL-NERVOUS-SYSTEM
KW - REGULATED ANION CHANNEL
KW - FREE AMINO ACIDS
KW - PITUITARY-ADRENAL AXIS
KW - PARKINSONS-DISEASE
UR - http://www.scopus.com/inward/record.url?scp=85029556764&partnerID=8YFLogxK
UR - http://www.mendeley.com/research/understanding-taurine-cns-activity-using-alternative-zebrafish-models
U2 - 10.1016/j.neubiorev.2017.09.008
DO - 10.1016/j.neubiorev.2017.09.008
M3 - Review article
AN - SCOPUS:85029556764
VL - 83
SP - 525
EP - 539
JO - Neuroscience and Biobehavioral Reviews
JF - Neuroscience and Biobehavioral Reviews
SN - 0149-7634
IS - December
ER -
ID: 9433875