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Understanding sex differences in zebrafish pain- and fear-related behaviors. / Marcon, Leticia; Giacomini, Ana C.V.V.; dos Santos, Bruna E.; Costa, Fabiano V.; Rosemberg, Denis B.; Demin, Konstantin A. ; Kalueff, Allan V. ; de Abreu, Murilo.

In: Neuroscience Letters, Vol. 772, 136412, 16.02.2022.

Research output: Contribution to journal › Article › peer-review

Harvard

Marcon, L, Giacomini, ACVV, dos Santos, BE, Costa, FV, Rosemberg, DB, Demin, KA, Kalueff, AV & de Abreu, M 2022, 'Understanding sex differences in zebrafish pain- and fear-related behaviors', Neuroscience Letters, vol. 772, 136412. https://doi.org/10.1016/j.neulet.2021.136412

APA

Marcon, L., Giacomini, A. C. V. V., dos Santos, B. E., Costa, F. V., Rosemberg, D. B., Demin, K. A., Kalueff, A. V., & de Abreu, M. (2022). Understanding sex differences in zebrafish pain- and fear-related behaviors. Neuroscience Letters, 772, [136412]. https://doi.org/10.1016/j.neulet.2021.136412

Vancouver

Marcon L, Giacomini ACVV, dos Santos BE, Costa FV, Rosemberg DB, Demin KA et al. Understanding sex differences in zebrafish pain- and fear-related behaviors. Neuroscience Letters. 2022 Feb 16;772. 136412. https://doi.org/10.1016/j.neulet.2021.136412

Author

Marcon, Leticia ; Giacomini, Ana C.V.V. ; dos Santos, Bruna E. ; Costa, Fabiano V. ; Rosemberg, Denis B. ; Demin, Konstantin A. ; Kalueff, Allan V. ; de Abreu, Murilo. / Understanding sex differences in zebrafish pain- and fear-related behaviors. In: Neuroscience Letters. 2022 ; Vol. 772.

BibTeX

@article{4700198d149045209c69b829896955e8,
title = "Understanding sex differences in zebrafish pain- and fear-related behaviors",
abstract = "Sex is an important variable in translational biomedical research. While overt sex differences have been reported for pain and fear-like behaviors in humans and rodents, these differences in other popular model organisms, such as zebrafish, remain poorly understood. Here, we evaluate potential sex differences in zebrafish behavioral responses to pain (intraperitoneal administration of 5% acetic acid) and fear stimuli (exposure to alarm substance). Overall, both male and female zebrafish exposed to pain (acetic acid injection) show lesser distance traveled, fewer top entries and more writhing-like pain-related behavior vs. controls, whereas female fish more robustly (than males) altered some other pain-like behaviors (e.g., increasing freezing episodes and time in top) in this model. In contrast, zebrafish of both sexes responded equally strongly to fear evoked by acute alarm substance exposure. Collectively, these findings emphasize the growing importance of studying sex differences in zebrafish behavioral and pain models.",
keywords = "Acetic acid, Alarm substance, Behavior, Sex differences, Zebrafish",
author = "Leticia Marcon and Giacomini, {Ana C.V.V.} and {dos Santos}, {Bruna E.} and Costa, {Fabiano V.} and Rosemberg, {Denis B.} and Demin, {Konstantin A.} and Kalueff, {Allan V.} and {de Abreu}, Murilo",
note = "Publisher Copyright: {\textcopyright} 2021 Elsevier B.V.",
year = "2022",
month = feb,
day = "16",
doi = "10.1016/j.neulet.2021.136412",
language = "English",
volume = "772",
journal = "Neuroscience Letters",
issn = "0304-3940",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Understanding sex differences in zebrafish pain- and fear-related behaviors

AU - Marcon, Leticia

AU - Giacomini, Ana C.V.V.

AU - dos Santos, Bruna E.

AU - Costa, Fabiano V.

AU - Rosemberg, Denis B.

AU - Demin, Konstantin A.

AU - Kalueff, Allan V.

AU - de Abreu, Murilo

N1 - Publisher Copyright: © 2021 Elsevier B.V.

PY - 2022/2/16

Y1 - 2022/2/16

N2 - Sex is an important variable in translational biomedical research. While overt sex differences have been reported for pain and fear-like behaviors in humans and rodents, these differences in other popular model organisms, such as zebrafish, remain poorly understood. Here, we evaluate potential sex differences in zebrafish behavioral responses to pain (intraperitoneal administration of 5% acetic acid) and fear stimuli (exposure to alarm substance). Overall, both male and female zebrafish exposed to pain (acetic acid injection) show lesser distance traveled, fewer top entries and more writhing-like pain-related behavior vs. controls, whereas female fish more robustly (than males) altered some other pain-like behaviors (e.g., increasing freezing episodes and time in top) in this model. In contrast, zebrafish of both sexes responded equally strongly to fear evoked by acute alarm substance exposure. Collectively, these findings emphasize the growing importance of studying sex differences in zebrafish behavioral and pain models.

AB - Sex is an important variable in translational biomedical research. While overt sex differences have been reported for pain and fear-like behaviors in humans and rodents, these differences in other popular model organisms, such as zebrafish, remain poorly understood. Here, we evaluate potential sex differences in zebrafish behavioral responses to pain (intraperitoneal administration of 5% acetic acid) and fear stimuli (exposure to alarm substance). Overall, both male and female zebrafish exposed to pain (acetic acid injection) show lesser distance traveled, fewer top entries and more writhing-like pain-related behavior vs. controls, whereas female fish more robustly (than males) altered some other pain-like behaviors (e.g., increasing freezing episodes and time in top) in this model. In contrast, zebrafish of both sexes responded equally strongly to fear evoked by acute alarm substance exposure. Collectively, these findings emphasize the growing importance of studying sex differences in zebrafish behavioral and pain models.

KW - Acetic acid

KW - Alarm substance

KW - Behavior

KW - Sex differences

KW - Zebrafish

UR - https://pubmed.ncbi.nlm.nih.gov/34942320/

UR - https://proxy.library.spbu.ru:2068/science/article/pii/S0304394021007916?via%3Dihub

UR - http://www.scopus.com/inward/record.url?scp=85122539025&partnerID=8YFLogxK

U2 - 10.1016/j.neulet.2021.136412

DO - 10.1016/j.neulet.2021.136412

M3 - Article

VL - 772

JO - Neuroscience Letters

JF - Neuroscience Letters

SN - 0304-3940

M1 - 136412

ER -

ID: 89620959