Stress response is essential for the organism to quickly restore physiological homeostasis disturbed by various environmental insults. In addition to well-established physiological cascades, stress also evokes various brain and behavioral responses. Aquatic animal models, including the zebrafish (Danio rerio), have been extensively used to probe pathobiological mechanisms of stress and stress-related brain disorders. Here, we critically discuss the use of zebrafish models for studying mechanisms of stress and modeling its disorders experimentally, with a particular cross-taxon focus on the potential evolution of stress responses from zebrafish to rodents and humans, as well as its translational implications.

Original languageEnglish
Article number100405
Number of pages11
JournalNeurobiology of Stress
Volume15
DOIs
StatePublished - Nov 2021

    Research areas

  • ACUTE RESTRAINT STRESS, Animal models, Behavior, Cortisol, DANIO-RERIO, NEUROTROPHIC FACTOR, PREFRONTAL CORTEX, PSYCHOLOGICAL STRESS, REPEATED SOCIAL DEFEAT, Rodents, SEX-DIFFERENCES, Stress axis, TANDEM MASS-SPECTROMETRY, TROUT ONCORHYNCHUS-MYKISS, WHOLE-BODY CORTISOL, Zebrafish

ID: 88779512