Research output: Contribution to journal › Article › peer-review
Understanding fear generalization in adult zebrafish in predator-based assays. / Jiang, JY; Wang, JY; Martynov, DD; Golushko, NI; Qin, YX; Zhang, YQ; Zhao, CG; Wang, CM; Liu, YC; Feng, HY; Cai, HL; He, K; He, SL; Li, RY; Galstyan, DS; Yang, L; de Abreu, MS; Kalueff, AV.
In: Behavioural Processes, Vol. 231, 2025.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - Understanding fear generalization in adult zebrafish in predator-based assays
AU - Jiang, JY
AU - Wang, JY
AU - Martynov, DD
AU - Golushko, NI
AU - Qin, YX
AU - Zhang, YQ
AU - Zhao, CG
AU - Wang, CM
AU - Liu, YC
AU - Feng, HY
AU - Cai, HL
AU - He, K
AU - He, SL
AU - Li, RY
AU - Galstyan, DS
AU - Yang, L
AU - de Abreu, MS
AU - Kalueff, AV
N1 - Times Cited in Web of Science Core Collection: 0 Total Times Cited: 0 Cited Reference Count: 152
PY - 2025
Y1 - 2025
N2 - Critical for behavioral adaptations to various natural threats, fear and its generalization have been extensively studied in mammals, including rodents and primates. The zebrafish (Danio rerio) represents a promising model organism for studying neurobiological bases of emotions and cognitions. Although fear generalization is critical for organismal survival, it remains poorly understood in zebrafish. To address this problem, here we applied a natural predator (Indian leaf fish, Nandus nandus) exposure in various contexts to systematically probe zebrafish behavioral strategies following this vital threat. Overall, our experiments show that zebrafish remember past exposure to a live predator and can generalize this information by avoiding both current and prior locations of the predator in the exposure tank. Collectively, this confirms that zebrafish are capable of generalizing predator fear, and employ advanced cognitive processes (similar to those observed in mammals) in their behavioral strategies when exposed to vital threats.
AB - Critical for behavioral adaptations to various natural threats, fear and its generalization have been extensively studied in mammals, including rodents and primates. The zebrafish (Danio rerio) represents a promising model organism for studying neurobiological bases of emotions and cognitions. Although fear generalization is critical for organismal survival, it remains poorly understood in zebrafish. To address this problem, here we applied a natural predator (Indian leaf fish, Nandus nandus) exposure in various contexts to systematically probe zebrafish behavioral strategies following this vital threat. Overall, our experiments show that zebrafish remember past exposure to a live predator and can generalize this information by avoiding both current and prior locations of the predator in the exposure tank. Collectively, this confirms that zebrafish are capable of generalizing predator fear, and employ advanced cognitive processes (similar to those observed in mammals) in their behavioral strategies when exposed to vital threats.
KW - Zebrafish
KW - Fear generalization
KW - Predator stress
KW - Memory
KW - Cognitive abilities
KW - Avoidance behavior
KW - DANIO-RERIO RESPONDS
KW - BEHAVIORAL-RESPONSES
KW - SEX-DIFFERENCES
KW - STIMULUS-GENERALIZATION
KW - NEUROSCIENCE RESEARCH
KW - POTENTIATED STARTLE
KW - ANXIETY DISORDER
KW - ANIMAL RESEARCH
KW - MEMORY
KW - STRESS
U2 - 10.1016/j.beproc.2025.105256
DO - 10.1016/j.beproc.2025.105256
M3 - статья
VL - 231
JO - Behavioural Processes
JF - Behavioural Processes
SN - 0376-6357
ER -
ID: 147902302