Standard

Tumor growth suppression after xenografting of human colorectal carcinoma cells. / Davydov-Sinitsyn, A. P.; Bajenova, O. V.; Liskovykh, M. A.; Ponomartsev, S. V.; Rykov, I. V.; Koshkin, S. A.; Orlova, R. V.; Tomilin, A. N.; Tolkunova, E. N.

In: Cell and Tissue Biology, Vol. 9, No. 4, 12.07.2015, p. 318-325.

Research output: Contribution to journal › Article › peer-review

Harvard

Davydov-Sinitsyn, AP, Bajenova, OV, Liskovykh, MA, Ponomartsev, SV, Rykov, IV, Koshkin, SA, Orlova, RV, Tomilin, AN & Tolkunova, EN 2015, 'Tumor growth suppression after xenografting of human colorectal carcinoma cells', Cell and Tissue Biology, vol. 9, no. 4, pp. 318-325. https://doi.org/10.1134/S1990519X15040045

APA

Davydov-Sinitsyn, A. P., Bajenova, O. V., Liskovykh, M. A., Ponomartsev, S. V., Rykov, I. V., Koshkin, S. A., Orlova, R. V., Tomilin, A. N., & Tolkunova, E. N. (2015). Tumor growth suppression after xenografting of human colorectal carcinoma cells. Cell and Tissue Biology, 9(4), 318-325. https://doi.org/10.1134/S1990519X15040045

Vancouver

Davydov-Sinitsyn AP, Bajenova OV, Liskovykh MA, Ponomartsev SV, Rykov IV, Koshkin SA et al. Tumor growth suppression after xenografting of human colorectal carcinoma cells. Cell and Tissue Biology. 2015 Jul 12;9(4):318-325. https://doi.org/10.1134/S1990519X15040045

Author

Davydov-Sinitsyn, A. P. ; Bajenova, O. V. ; Liskovykh, M. A. ; Ponomartsev, S. V. ; Rykov, I. V. ; Koshkin, S. A. ; Orlova, R. V. ; Tomilin, A. N. ; Tolkunova, E. N. / Tumor growth suppression after xenografting of human colorectal carcinoma cells. In: Cell and Tissue Biology. 2015 ; Vol. 9, No. 4. pp. 318-325.

BibTeX

@article{41b9eb3f291d487aae145cea6c5d64e7,
title = "Tumor growth suppression after xenografting of human colorectal carcinoma cells",
abstract = "Previously, we have described the establishment of a subpopulation of cancer stem cells from the human colorectal carcinoma cell line MIP101. These cells exhibit enhanced clonogenic and tumorigenic capacities. Depletion of the stem compartment in the cancer cell population blocks its tumorigenicity. The present work is dedicated to a comparison of the tumorigenic potential of cell populations with an enriched or depleted stem compartment. We showed that tumor growth after xenografting of an enriched stem cell population can be suppressed by intramuscular injections of ganciclovir. Thus, we suggest an approach to isolating a cell population with high Oct4 promoter expression in the MIP101 colorectal carcinoma line and eliminating these cells from the population in vitro as well as in vivo.",
keywords = "cancer stem cells, Oct4, tumorigenicity",
author = "Davydov-Sinitsyn, {A. P.} and Bajenova, {O. V.} and Liskovykh, {M. A.} and Ponomartsev, {S. V.} and Rykov, {I. V.} and Koshkin, {S. A.} and Orlova, {R. V.} and Tomilin, {A. N.} and Tolkunova, {E. N.}",
note = "Publisher Copyright: {\textcopyright} 2015, Pleiades Publishing, Ltd. Copyright: Copyright 2015 Elsevier B.V., All rights reserved.",
year = "2015",
month = jul,
day = "12",
doi = "10.1134/S1990519X15040045",
language = "English",
volume = "9",
pages = "318--325",
journal = "Cell and Tissue Biology",
issn = "1990-519X",
publisher = "МАИК {"}Наука/Интерпериодика{"}",
number = "4",

}

RIS

TY - JOUR

T1 - Tumor growth suppression after xenografting of human colorectal carcinoma cells

AU - Davydov-Sinitsyn, A. P.

AU - Bajenova, O. V.

AU - Liskovykh, M. A.

AU - Ponomartsev, S. V.

AU - Rykov, I. V.

AU - Koshkin, S. A.

AU - Orlova, R. V.

AU - Tomilin, A. N.

AU - Tolkunova, E. N.

N1 - Publisher Copyright: © 2015, Pleiades Publishing, Ltd. Copyright: Copyright 2015 Elsevier B.V., All rights reserved.

PY - 2015/7/12

Y1 - 2015/7/12

N2 - Previously, we have described the establishment of a subpopulation of cancer stem cells from the human colorectal carcinoma cell line MIP101. These cells exhibit enhanced clonogenic and tumorigenic capacities. Depletion of the stem compartment in the cancer cell population blocks its tumorigenicity. The present work is dedicated to a comparison of the tumorigenic potential of cell populations with an enriched or depleted stem compartment. We showed that tumor growth after xenografting of an enriched stem cell population can be suppressed by intramuscular injections of ganciclovir. Thus, we suggest an approach to isolating a cell population with high Oct4 promoter expression in the MIP101 colorectal carcinoma line and eliminating these cells from the population in vitro as well as in vivo.

AB - Previously, we have described the establishment of a subpopulation of cancer stem cells from the human colorectal carcinoma cell line MIP101. These cells exhibit enhanced clonogenic and tumorigenic capacities. Depletion of the stem compartment in the cancer cell population blocks its tumorigenicity. The present work is dedicated to a comparison of the tumorigenic potential of cell populations with an enriched or depleted stem compartment. We showed that tumor growth after xenografting of an enriched stem cell population can be suppressed by intramuscular injections of ganciclovir. Thus, we suggest an approach to isolating a cell population with high Oct4 promoter expression in the MIP101 colorectal carcinoma line and eliminating these cells from the population in vitro as well as in vivo.

KW - cancer stem cells

KW - Oct4

KW - tumorigenicity

UR - http://www.scopus.com/inward/record.url?scp=84938830001&partnerID=8YFLogxK

U2 - 10.1134/S1990519X15040045

DO - 10.1134/S1990519X15040045

M3 - Article

AN - SCOPUS:84938830001

VL - 9

SP - 318

EP - 325

JO - Cell and Tissue Biology

JF - Cell and Tissue Biology

SN - 1990-519X

IS - 4

ER -

ID: 75177089