Transition-metal-free intramolecular double hydrofunctionalization of alkyne to access 6/7/5-fused heterocyclic skeletons

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Transition-metal-free intramolecular double hydrofunctionalization of alkyne to access 6/7/5-fused heterocyclic skeletons. / Aghaie, Kimia; Amiri, Kamran; Rezaei-Gohar, Mohammad; Rominger, Frank; Дарьин, Дмитрий Викторович ; Сапегин, Александр Владимирович; Balalaie, Saeed.

In: Chemical Communications, 07.02.2024.

Research output: Contribution to journal › Article › peer-review

BibTeX

@article{7e811bd151294de7940c703dfb3f85cc,

title = "Transition-metal-free intramolecular double hydrofunctionalization of alkyne to access 6/7/5-fused heterocyclic skeletons",

abstract = "We have disclosed a novel functionalized isonitrile scaffold containing alkyne moiety and designed a new intramolecular double hydrofunctionalization cyclization of alkyne, that affords access to valuable 6/7/5-fused heterocyclic scaffolds.We describe a novel intramolecular double hydrofunctionalization cyclization of alkyne with nitrogen and oxygen nucleophilic groups to construct valuable 6/7/5-fused heterocyclic products. This post-Groebke–Blackburn–Bienaym{\'e} (GBB) reaction introduces a new class of functionalized isocyanides. Transition-metal-free cyclization, broad substrate scope, and high atom economy were some features of the present protocol.",

author = "Kimia Aghaie and Kamran Amiri and Mohammad Rezaei-Gohar and Frank Rominger and Дарьин, {Дмитрий Викторович} and Сапегин, {Александр Владимирович} and Saeed Balalaie",

year = "2024",

month = feb,

day = "7",

doi = "10.1039/D3CC05724K",

language = "English",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

}

RIS

TY - JOUR

T1 - Transition-metal-free intramolecular double hydrofunctionalization of alkyne to access 6/7/5-fused heterocyclic skeletons

AU - Aghaie, Kimia

AU - Amiri, Kamran

AU - Rezaei-Gohar, Mohammad

AU - Rominger, Frank

AU - Дарьин, Дмитрий Викторович

AU - Сапегин, Александр Владимирович

AU - Balalaie, Saeed

PY - 2024/2/7

Y1 - 2024/2/7

N2 - We have disclosed a novel functionalized isonitrile scaffold containing alkyne moiety and designed a new intramolecular double hydrofunctionalization cyclization of alkyne, that affords access to valuable 6/7/5-fused heterocyclic scaffolds.We describe a novel intramolecular double hydrofunctionalization cyclization of alkyne with nitrogen and oxygen nucleophilic groups to construct valuable 6/7/5-fused heterocyclic products. This post-Groebke–Blackburn–Bienaymé (GBB) reaction introduces a new class of functionalized isocyanides. Transition-metal-free cyclization, broad substrate scope, and high atom economy were some features of the present protocol.

AB - We have disclosed a novel functionalized isonitrile scaffold containing alkyne moiety and designed a new intramolecular double hydrofunctionalization cyclization of alkyne, that affords access to valuable 6/7/5-fused heterocyclic scaffolds.We describe a novel intramolecular double hydrofunctionalization cyclization of alkyne with nitrogen and oxygen nucleophilic groups to construct valuable 6/7/5-fused heterocyclic products. This post-Groebke–Blackburn–Bienaymé (GBB) reaction introduces a new class of functionalized isocyanides. Transition-metal-free cyclization, broad substrate scope, and high atom economy were some features of the present protocol.

UR - https://www.mendeley.com/catalogue/c65cc0d7-38f2-38f1-9e19-2392e9597891/

U2 - 10.1039/D3CC05724K

DO - 10.1039/D3CC05724K

M3 - Article

JO - Chemical Communications

JF - Chemical Communications

SN - 1359-7345

ER -

ID: 117215099