Transient neurochemical features of the perigeniculate neurons during early postnatal development of the cat. / Меркульева, Наталья Сергеевна; Михалкин, Александр ; Костарева, Анна Александровна; Вавилова, Татьяна Дмитриевна.
In: Journal of Comparative Neurology, Vol. 530, No. 18, 12.2022, p. 3193-3208.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - Transient neurochemical features of the perigeniculate neurons during early postnatal development of the cat
AU - Меркульева, Наталья Сергеевна
AU - Михалкин, Александр
AU - Костарева, Анна Александровна
AU - Вавилова, Татьяна Дмитриевна
N1 - Publisher Copyright: © 2022 Wiley Periodicals LLC.
PY - 2022/12
Y1 - 2022/12
N2 - The thalamic reticular nucleus receives axons from the thalamic sensory nuclei and the cerebral cortex. The visual part of this nucleus in carnivores is the perigeniculate nucleus located dorsal to the lateral geniculate nucleus. The perigeniculate nucleus participates in the modulation of visual processing and in the transition of synchronized slow rhythmicity during sleep into desynchronized high-frequency activity during arousal and consists of inhibitory neurons. The main neurochemical markers for perigeniculate neurons are glutamic acid decarboxylase and Ca 2+-binding protein parvalbumin. Previous studies of postnatal development focused on the morphological features of the perigeniculate nucleus; however, its neurochemistry remains poorly understood. In this study, we focused on the postnatal development of perigeniculate neurons using immunohistochemical labeling of parvalbumin, two related Ca 2+-binding proteins (calretinin and calbindin), glutamic acid decarboxylase, and a common neuronal protein, NeuN, in kittens that were 0–123 days old and in adult cats. In parallel with the well-known dominant neuronal populations expressing parvalbumin and GAD67 and persisting until adulthood, transient populations expressing calretinin and calbindin were observed. The calbindin-positive neurons were similar to the main perigeniculate population and showed close morphological features and parvalbumin coexpression. In contrast, the calretinin-positive neurons differed in their morphological characteristics and did not express GAD67, thus distinguishing them from the majority of perigeniculate neurons. A possible link between these populations was revealed, and the development of thalamocortical processing is discussed.
AB - The thalamic reticular nucleus receives axons from the thalamic sensory nuclei and the cerebral cortex. The visual part of this nucleus in carnivores is the perigeniculate nucleus located dorsal to the lateral geniculate nucleus. The perigeniculate nucleus participates in the modulation of visual processing and in the transition of synchronized slow rhythmicity during sleep into desynchronized high-frequency activity during arousal and consists of inhibitory neurons. The main neurochemical markers for perigeniculate neurons are glutamic acid decarboxylase and Ca 2+-binding protein parvalbumin. Previous studies of postnatal development focused on the morphological features of the perigeniculate nucleus; however, its neurochemistry remains poorly understood. In this study, we focused on the postnatal development of perigeniculate neurons using immunohistochemical labeling of parvalbumin, two related Ca 2+-binding proteins (calretinin and calbindin), glutamic acid decarboxylase, and a common neuronal protein, NeuN, in kittens that were 0–123 days old and in adult cats. In parallel with the well-known dominant neuronal populations expressing parvalbumin and GAD67 and persisting until adulthood, transient populations expressing calretinin and calbindin were observed. The calbindin-positive neurons were similar to the main perigeniculate population and showed close morphological features and parvalbumin coexpression. In contrast, the calretinin-positive neurons differed in their morphological characteristics and did not express GAD67, thus distinguishing them from the majority of perigeniculate neurons. A possible link between these populations was revealed, and the development of thalamocortical processing is discussed.
KW - GAD
KW - NeuN
KW - calbindin
KW - calretinin
KW - cat
KW - parvalbumin
KW - perigeniculate nucleus
KW - postnatal development
UR - http://www.scopus.com/inward/record.url?scp=85136901493&partnerID=8YFLogxK
UR - https://www.mendeley.com/catalogue/eede548b-0e18-3313-a813-5987ef951737/
U2 - 10.1002/cne.25402
DO - 10.1002/cne.25402
M3 - Article
VL - 530
SP - 3193
EP - 3208
JO - Journal of Comparative Neurology
JF - Journal of Comparative Neurology
SN - 0021-9967
IS - 18
ER -
ID: 98095368