TY - JOUR

T1 - Transcriptional noise as a driver of gene evolution

AU - Polev, D.

PY - 2012

Y1 - 2012

N2 - As novel genes emerge in the evolution of species, pre-existing genes expand their expression patterns to diversify their functions and the expression patterns of gene duplicates diverge to pursue functional specialization. All these processes require genes to be expressed, however, the level and specificity of gene expression at the early stages of these processes are unclear. In this study, I propose that transcriptional noise is a mechanism to test genes for new functions, and I hypothesize the 'in-service' mechanism of gene evolution. In contrast to other hypotheses that suggest that there are specialized sites for gene evolution, such as tumors (Kozlov, 2010) or the testis (Kaessmann, 2010) this hypothesis proposes that emerging genes are expressed nonspecifically in many normal tissues, due to transcriptional noise. New genes are continuously 'tested' in various cells and under various conditions, thereby allowing the genes to evolve functions at the sites of their future work. The hypothesis of 'in-ser

AB - As novel genes emerge in the evolution of species, pre-existing genes expand their expression patterns to diversify their functions and the expression patterns of gene duplicates diverge to pursue functional specialization. All these processes require genes to be expressed, however, the level and specificity of gene expression at the early stages of these processes are unclear. In this study, I propose that transcriptional noise is a mechanism to test genes for new functions, and I hypothesize the 'in-service' mechanism of gene evolution. In contrast to other hypotheses that suggest that there are specialized sites for gene evolution, such as tumors (Kozlov, 2010) or the testis (Kaessmann, 2010) this hypothesis proposes that emerging genes are expressed nonspecifically in many normal tissues, due to transcriptional noise. New genes are continuously 'tested' in various cells and under various conditions, thereby allowing the genes to evolve functions at the sites of their future work. The hypothesis of 'in-ser

KW - Tumor

KW - testis

KW - transcriptional noise

KW - in-service evolution

U2 - 10.1016/j.jtbi.2011.10.001

DO - 10.1016/j.jtbi.2011.10.001

M3 - статья

VL - 293

SP - 27

EP - 33

JO - Journal of Theoretical Biology

JF - Journal of Theoretical Biology

SN - 0022-5193

ER -