TY - JOUR

T1 - Trace Amine-Associated Receptors’ Role in Immune System Functions

AU - Moiseenko, Vyacheslav I.

AU - Apryatina, Vera A.

AU - Gainetdinov, Raul R.

AU - Apryatin, Sergey A.

PY - 2024/4/18

Y1 - 2024/4/18

N2 - Trace amines are a separate, independent group of biogenic amines, close in structure to classical monoamine neurotransmitters such as dopamine, serotonin, and norepinephrine that include many products of the endogenous or bacteria-mediated decarboxylation of amino acids. A family of G protein-coupled trace amine-associated receptors (in humans, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, and TAAR9) that senses trace amines was discovered relatively recently. They are mostly investigated for their involvement in the olfaction of volatile amines encoding innate behaviors and their potential contribution to the pathogenesis of neuropsychiatric disorders, but the expression of the TAAR family of receptors is also observed in various populations of cells in the immune system. This review is focused on the basic information of the interaction of trace amines and their receptors with cells of the general immune systems of humans and other mammals. We also overview the available data on TAARs’ role in the function of individual populations of myeloid and lymphoidcells. With further research on the regulatory role of the trace amine system in immune functions and on uncovering the contribution of these processes to the pathogenesis of the immune response, a significant advance in the field could be expected. Furthermore, the determination of the molecular mechanisms of TAARs’ involvement in immune system regulation and the further investigationof their potential chemotactic role could bring about the development of new approaches for the treatment of disorders related to immune system dysfunctions.

AB - Trace amines are a separate, independent group of biogenic amines, close in structure to classical monoamine neurotransmitters such as dopamine, serotonin, and norepinephrine that include many products of the endogenous or bacteria-mediated decarboxylation of amino acids. A family of G protein-coupled trace amine-associated receptors (in humans, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, and TAAR9) that senses trace amines was discovered relatively recently. They are mostly investigated for their involvement in the olfaction of volatile amines encoding innate behaviors and their potential contribution to the pathogenesis of neuropsychiatric disorders, but the expression of the TAAR family of receptors is also observed in various populations of cells in the immune system. This review is focused on the basic information of the interaction of trace amines and their receptors with cells of the general immune systems of humans and other mammals. We also overview the available data on TAARs’ role in the function of individual populations of myeloid and lymphoidcells. With further research on the regulatory role of the trace amine system in immune functions and on uncovering the contribution of these processes to the pathogenesis of the immune response, a significant advance in the field could be expected. Furthermore, the determination of the molecular mechanisms of TAARs’ involvement in immune system regulation and the further investigationof their potential chemotactic role could bring about the development of new approaches for the treatment of disorders related to immune system dysfunctions.

KW - G protein-coupled receptors

KW - TAAR

KW - immune system

KW - lymphoid cells

KW - myeloid cells

KW - trace amine-associated receptors

KW - trace amines

UR - https://www.mendeley.com/catalogue/92e75d7f-390d-331f-8bf2-32fb425ab92b/

U2 - 10.3390/biomedicines12040893

DO - 10.3390/biomedicines12040893

M3 - Review article

C2 - 38672247

VL - 12

JO - Biomedicines

JF - Biomedicines

SN - 2227-9059

IS - 4

M1 - 893

ER -