TY - JOUR

T1 - Trace amine-associated receptors at the cross-road between innate olfaction of amines, emotions, and adult neurogenesis

AU - Efimova, Evgeniya V.

AU - Katolikova, Nataliia V.

AU - Kanov, Evgeny V.

AU - Gainetdinov, Raul R.

N1 - Funding Information: an increased level of glial derived neurotrophic et al., 2016). Thus, TAARs may play a key role before publication ? factor (GDNF) in the striatum (Efimova et al., in the junction that connects trace amines, lagiarism check 圀C hecked twice by iThenticate ? 2021). Neurotrophic factors, such as GDNF, are emotional behavior (and, in particular, mood ?eer review 圀Ex ternally peer reviewed ? the proteins required for differentiation and disorders), and adult neurogenesis. As many of Open access statement 圀Th is is an open access survival of neurons during development, as well the aspects of TAAR5 receptor functions and journal 唀 and articles are distributed under the as maintenance of the adult nervous system. mechanisms of actions is yet to be determined 唀 G?NF is known to be particularly important for it is clear now, that it should not be considered terms of the Creative Commons Attribution ? dopaminergic neuron functioning 堀 In embryonic as only an olfactory receptor, but also as a NonCommercial 爀ShareAlike 堃 License 唀 which midbrain cell cultures, GDNF promotes the neuronal receptor involved in the regulation of allows others to remix 唀 tweak 唀 and build upon the survival and morphological differentiation of brain neurochemistry, adult neurogenesis and work non 爁?ommercially唀 as long as appropriate dopaminergic neurons while administration of emotional behavior 堀 The olfaction and patterns credit is given and the new creations are licensed G?NF into the adult rats Substantia Nigra could of adult neurogenesis in the SVZ and SGZ are under the identical terms 堀 stimulate dopaminergic neuronal function different between humans and rodents. It (Barker et al., 2020). Taken together, these has been reported that TAAR5 is expressed data suggest the increased dopamine neuron in olfactory sensory neurons and amygdala in References proliferation either during development or humans (discussed in Espinoza et al., 2020). Barker RA, Björklund A, Gash DM, Whone A, Van Laar in adult TAAR5-KO mice. One highly debated Whether similar to mouse patterns of TAAR5 A, Kordower JH, Bankiewicz K, Kieburtz K, Saarma M, possibility suggests that adult neurogenesis expression occur in other human brain areas Booms S 唀 ?uttunen ?J唀 ?ells A?唀 Fiandaca MS 唀 Stoessl of the dopamine neurons might occur at ?particularlylimbic andneurogenic structures? AJ唀 Eidelberg ?唀 Federoff ?唀 V outilainen M 唀 e xter potentially neurogenic zone surrounding the requires further detailed studies. Nevertheless, DT, Eberling J, Brundin P, et al. (2020) GDNF and 3rd ventricle (Jurkowski et al., 2020). It is well one can propose that selective antagonists of Parkinson’s disease: where next? A summary from a established that adult neurogenesis in mammals TAAR5 may in the future become principally recent workshop. J Parkinsons Dis 10:875-891. occurs primarily in twoareas: thesubventricular new psychotropic medications and expand Belov R 唀 E fimova EV唀 Fesenko S 唀 An tonova ?A唀 zone (SVZ), which is located in the walls of the options of pharmacotherapy of depression, Kolodyazhny SF, Lakstygal AM, Gainetdinov RR (2020) lateral ventricles of the brain and connected anxiety, and/or neurodegenerative disorders ?utative trace 爁ȁ甁崁瘁Ḁ associated receptor  縀TAAR 缀 through the rostral migration stream with an such as Parkinson’s Disorder (Espinoza et agonist α 爀NETA increases electrocorticogram gamma ? olfactory bulb, and the subgranular zone (SGZ) al., 2020; Efimova et al., 2021). Finally, it rhythm in freely moving rats. Cell Mol Neurobiol of the dentate gyrus of the hippocampus, that is would be important to explore if other TAARs 40:203-213. mostly involvedinmemory formation??owever?will be acting as TAAR5 by being expressed Berry MD, Gainetdinov RR, Hoener MC, Shahid M (2017) the recent evidence suggests that adult in limbic brain areas and involved in the Pharmacology of human trace amine-associated neurogenesis can also occur in other potentially regulation of emotional behaviors and adult receptors 圀 therapeutic opportunities and challenges 堀 neurogenic zones such as the striatum, the neurogenesis. However, we expect that since Pharmacol Ther 180:161-180. hypothalamus, the neocortex, and the areas different TAARs are known to be activated Efimova EV唀 ?ozlova AA唀 Razenkova V唀 ?atolikova surrounding the 3rd ventricle (Jurkowski et by a selective set of products of amino acid NV, Antonova KA, Sotnikova TD, Merkulyeva NS, al., 2020). Importantly, LacZ staining showed decarboxylation 縀Gainetdinov et al 堃唀 V缀esh cahnitdskii AS, Kalinina DS, Korzhevskii DE, Musienko that TAAR5 is expressed in areas canonical for project to discrete glomeruli (Liberles, 2015), PE, Kanov EV, Gainetdinov RR (2021) Increased adult neurogenesis, SVZ, and SGZ, but also their involvement in these processes will be dopamine transmission and adult neurogenesis in in areas surrounding the 3rd ventricle. Some likely variable. In fact, in preliminary studies trace amine-associated receptor 5 (TAAR5) knockout LacZ/TAAR5-positive cells were found also in TAAR2-KO mice we did observe a similar, mice. Neuropharmacology 182:108373. along blood vessels, known to be involved in but not identical, pattern of brain TAAR2 Espinoza S 唀 Sukhanov I 唀 Efimova EV唀 ?ozlova A唀 Antonova the migration of proliferating neurons. These expression in limbic areas as well as alterations KA, Illiano P, Leo D, Merkulyeva N, Kalinina D, Musienko observations prompted us to evaluate adult in monoamine levels, emotional behaviors P, Rocchi A, Mus L, Sotnikova TD, Gainetdinov RR (2020) neurogenesis events in these areas directly. and adult neurogenesis (Kuvarzin et al., 2020). Trace amine-associated receptor 5 provides olfactory Analysis of doublecortin-positive (neuroblast-These studies eventually could provide the input into limbic brain areas and modulates emotional like) and PCNA-positive (proliferating) cells foundation of new pharmacological strategies behaviors and serotonin transmission. Front Mol showed that TAAR5-KO mice have an increased based on targeting TAARs in general ? that may Neurosci 13:18. number of neuroblastoid and proliferating cells represent a novel multifaceted approach for Gainetdinov RR, Hoener MC, Berry MD (2018) Trace in the SVZ and SGZ zones. At the same time, the treatment of a variety of psychiatric and amines and their receptors. Pharmacol Rev 70:549- no doublecortin-or PCNA-positive cells were neurodegenerative disorders 堀 620. found in the area surrounding the 3rd ventricle Jacobs BL, van Praag H, Gage FH (2000) Adult brain in wild type or TAAR5-KO mice precluding us The present work was supported by Russian neurogenesis and psychiatry: a novel theory of from making any conclusion on the status Science Foundation grant 爃爃d epression. Mol Psychiatry 5:262-269. of neurogenesis in this area (Efimova et al., 縁?o RRG 缃? Jurkowski M?唀 Bettio L唀 ?W oo E 唀 ? atten A唀 Yau SY唀 Gil ? 缃堀 Further detailed studies with additional Mohapel J (2020) Beyond the hippocampus and the of increase of the number of dopaminergic cells markers are neededto explainthe mechanism Evgeniya V 堀 Efimova 唀 Cell Neurosci 4:576444. SVZ: adult neurogenesis throughout the brain. Front Nataliia V 堀 Katolikova 唀 Evgeny V 堀 Kanov 唀 in TAAR5-KOmice. It would beimportant also Raul R 堀 Gainetdino?v Koblan KS, Kent J, Hopkins SC, Krystal JH, Cheng H, surrounding ventricles, as observed with TAAR5,to test the hypothesis if TAARs located in areas Institute of Translational Biomedicine and Saint binding drug for the treatment of schizophrenia. N Goldman R, Loebel A (2020) A non-D2-receptor-

PY - 2022/6

Y1 - 2022/6

UR - http://www.scopus.com/inward/record.url?scp=85120447278&partnerID=8YFLogxK

UR - https://www.mendeley.com/catalogue/850cf2f1-31a3-3779-b642-c2d9b7b8314b/

U2 - 10.4103/1673-5374.327338

DO - 10.4103/1673-5374.327338

M3 - Article

AN - SCOPUS:85120447278

VL - 17

SP - 1257

EP - 1258

JO - Neural Regeneration Research

JF - Neural Regeneration Research

SN - 1673-5374

IS - 6

ER -