TY - JOUR

T1 - Trace amine signaling in zebrafish models

T2 - CNS pharmacology, behavioral regulation and translational relevance

AU - Galstyan, David S

AU - Krotova, Natalia A

AU - Lebedev, Andrey S

AU - Kotova, Maria M

AU - Martynov, Daniil D

AU - Golushko, Nikita I

AU - Perederiy, Alexander S

AU - Zhukov, Ilya S

AU - Rosemberg, Denis B

AU - Lim, Lee Wei

AU - Yang, LongEn

AU - de Abreu, Murilo S

AU - Gainetdinov, Raul R

AU - Kalueff, Allan V

N1 - Copyright © 2025 Elsevier B.V. All rights reserved.

PY - 2025/3/15

Y1 - 2025/3/15

N2 - Tyramine, β-phenylethylamine, octopamine and other trace amines are endogenous substances recently recognized as important novel neurotransmitters in the brain. Trace amines act via multiple selective trace amine-associated receptors (TAARs) of the G protein-coupled receptor family. TAARs are expressed in various brain regions and modulate neurotransmission, neuronal excitability, adult neurogenesis, cognition, mood, locomotor activity and olfaction. Disrupted trace amine circuits have been implicated in various clinical neuropsychiatric disorders, including schizophrenia, Parkinson's disease, addiction, depression and anxiety. Dysregulated TAAR signaling has been linked in rodents to altered dopamine and serotonin neurotransmission, known to be associated with these psychiatric conditions. Complementing rodent genetic and pharmacological evidence, zebrafish (Danio rerio) are rapidly becoming a novel powerful model system in translational neuropharmacology research. Here, we review trace amine/TAAR neurobiology in zebrafish and discuss their developing translational utility as pharmacological and genetic models for unraveling the role of trace amines in CNS processes and brain disorders.

AB - Tyramine, β-phenylethylamine, octopamine and other trace amines are endogenous substances recently recognized as important novel neurotransmitters in the brain. Trace amines act via multiple selective trace amine-associated receptors (TAARs) of the G protein-coupled receptor family. TAARs are expressed in various brain regions and modulate neurotransmission, neuronal excitability, adult neurogenesis, cognition, mood, locomotor activity and olfaction. Disrupted trace amine circuits have been implicated in various clinical neuropsychiatric disorders, including schizophrenia, Parkinson's disease, addiction, depression and anxiety. Dysregulated TAAR signaling has been linked in rodents to altered dopamine and serotonin neurotransmission, known to be associated with these psychiatric conditions. Complementing rodent genetic and pharmacological evidence, zebrafish (Danio rerio) are rapidly becoming a novel powerful model system in translational neuropharmacology research. Here, we review trace amine/TAAR neurobiology in zebrafish and discuss their developing translational utility as pharmacological and genetic models for unraveling the role of trace amines in CNS processes and brain disorders.

KW - Animals

KW - Zebrafish/metabolism

KW - Signal Transduction/drug effects

KW - Receptors, G-Protein-Coupled/metabolism

KW - Behavior, Animal/drug effects

KW - Humans

KW - Central Nervous System/drug effects

KW - Translational Research, Biomedical

KW - Amines/metabolism

KW - Disease Models, Animal

KW - Behavioral deficits

KW - Adult neurogenesis

KW - Trace amine-associated receptors

KW - Zebrafish

KW - Neuropsychiatric disorders

KW - Trace amines

UR - https://www.mendeley.com/catalogue/d8c67153-57c5-360e-9855-c7bfdcbd4b52/

U2 - 10.1016/j.ejphar.2025.177312

DO - 10.1016/j.ejphar.2025.177312

M3 - Review article

C2 - 39870233

VL - 991

JO - European Journal of Pharmacology

JF - European Journal of Pharmacology

SN - 0014-2999

M1 - 177312

ER -