Trace amine associated receptor 1 and movement control. / Sotnikova, Tatyana D.; Zorina, Olesya I.; Ghisi, Valentina; Caron, Marc G.; Gainetdinov, Raul R.
In: Parkinsonism and Related Disorders, Vol. 14, No. SUPPL.2, 01.07.2008.Research output: Contribution to journal › Article › peer-review
}
TY - JOUR
T1 - Trace amine associated receptor 1 and movement control
AU - Sotnikova, Tatyana D.
AU - Zorina, Olesya I.
AU - Ghisi, Valentina
AU - Caron, Marc G.
AU - Gainetdinov, Raul R.
PY - 2008/7/1
Y1 - 2008/7/1
N2 - The recently discovered trace amine associated receptors (TAARs) represent attractive potential mediators of certain aspects of movement control. The TAAR that is best characterized, TAAR1, is particularly interesting because it can be activated by a variety of monoaminergic compounds including trace amines, amphetamines and dopamine metabolites. By using an experimental paradigm developed in our laboratory that involves a novel model of acute dopamine deficiency (DDD mice), and mice lacking TAAR1 (TAAR1 knockout mice), we explored the role of TAAR1 in movement control and actions of antiparkinsonian drugs. These investigations may eventually bring novel approaches to the pharmacology of Parkinson's disease.
AB - The recently discovered trace amine associated receptors (TAARs) represent attractive potential mediators of certain aspects of movement control. The TAAR that is best characterized, TAAR1, is particularly interesting because it can be activated by a variety of monoaminergic compounds including trace amines, amphetamines and dopamine metabolites. By using an experimental paradigm developed in our laboratory that involves a novel model of acute dopamine deficiency (DDD mice), and mice lacking TAAR1 (TAAR1 knockout mice), we explored the role of TAAR1 in movement control and actions of antiparkinsonian drugs. These investigations may eventually bring novel approaches to the pharmacology of Parkinson's disease.
KW - Amphetamine
KW - Dopamine
KW - L-dopa
KW - TAAR1
KW - Trace amine
UR - http://www.scopus.com/inward/record.url?scp=47049100558&partnerID=8YFLogxK
U2 - 10.1016/j.parkreldis.2008.04.006
DO - 10.1016/j.parkreldis.2008.04.006
M3 - Article
C2 - 18585080
AN - SCOPUS:47049100558
VL - 14
JO - Parkinsonism and Related Disorders
JF - Parkinsonism and Related Disorders
SN - 1353-8020
IS - SUPPL.2
ER -
ID: 36305833