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Towards translational modeling of behavioral despair and its treatment in zebrafish. / Kositsyn, Yuriy M H B; Volgin, Andrew D; de Abreu, Murilo S; Demin, Konstantin A; Zabegalov, Konstantin N; Maslov, Gleb O; Petersen, Elena V; Kolesnikova, Tatiana O; Strekalova, Tatiana; Kalueff, Allan V.

In: Behavioural Brain Research, Vol. 430, 113906, 26.07.2022.

Research output: Contribution to journal › Review article › peer-review

Harvard

Kositsyn, YMHB, Volgin, AD, de Abreu, MS, Demin, KA, Zabegalov, KN, Maslov, GO, Petersen, EV, Kolesnikova, TO, Strekalova, T & Kalueff, AV 2022, 'Towards translational modeling of behavioral despair and its treatment in zebrafish', Behavioural Brain Research, vol. 430, 113906. https://doi.org/10.1016/j.bbr.2022.113906

APA

Kositsyn, Y. M. H. B., Volgin, A. D., de Abreu, M. S., Demin, K. A., Zabegalov, K. N., Maslov, G. O., Petersen, E. V., Kolesnikova, T. O., Strekalova, T., & Kalueff, A. V. (2022). Towards translational modeling of behavioral despair and its treatment in zebrafish. Behavioural Brain Research, 430, [113906]. https://doi.org/10.1016/j.bbr.2022.113906

Vancouver

Kositsyn YMHB, Volgin AD, de Abreu MS, Demin KA, Zabegalov KN, Maslov GO et al. Towards translational modeling of behavioral despair and its treatment in zebrafish. Behavioural Brain Research. 2022 Jul 26;430. 113906. https://doi.org/10.1016/j.bbr.2022.113906

Author

Kositsyn, Yuriy M H B ; Volgin, Andrew D ; de Abreu, Murilo S ; Demin, Konstantin A ; Zabegalov, Konstantin N ; Maslov, Gleb O ; Petersen, Elena V ; Kolesnikova, Tatiana O ; Strekalova, Tatiana ; Kalueff, Allan V. / Towards translational modeling of behavioral despair and its treatment in zebrafish. In: Behavioural Brain Research. 2022 ; Vol. 430.

BibTeX

@article{197b1aff5b3c41b8840e8df0f9835282,
title = "Towards translational modeling of behavioral despair and its treatment in zebrafish",
abstract = "Depression is a widespread and severely debilitating neuropsychiatric disorder whose key clinical symptoms include low mood, anhedonia and despair (the inability or unwillingness to overcome stressors). Experimental animal models are widely used to improve our mechanistic understanding of depression pathogenesis, and to develop novel antidepressant therapies. In rodents, various experimental models of 'behavioral despair' have already been developed and rigorously validated. Complementing rodent studies, the zebrafish (Danio rerio) is emerging as a powerful model organism to assess pathobiological mechanisms of depression and other related affective disorders. Here, we critically discuss the developing potential and important translational implications of zebrafish models for studying despair and its mechanisms, and the utility of such aquatic models for antidepressant drug screening.",
keywords = "Animal models, Antidepressant, Behavior, Despair, Zebrafish",
author = "Kositsyn, {Yuriy M H B} and Volgin, {Andrew D} and {de Abreu}, {Murilo S} and Demin, {Konstantin A} and Zabegalov, {Konstantin N} and Maslov, {Gleb O} and Petersen, {Elena V} and Kolesnikova, {Tatiana O} and Tatiana Strekalova and Kalueff, {Allan V}",
note = "Publisher Copyright: {\textcopyright} 2022 Elsevier B.V.",
year = "2022",
month = jul,
day = "26",
doi = "10.1016/j.bbr.2022.113906",
language = "English",
volume = "430",
journal = "Behavioural Brain Research",
issn = "0166-4328",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Towards translational modeling of behavioral despair and its treatment in zebrafish

AU - Kositsyn, Yuriy M H B

AU - Volgin, Andrew D

AU - de Abreu, Murilo S

AU - Demin, Konstantin A

AU - Zabegalov, Konstantin N

AU - Maslov, Gleb O

AU - Petersen, Elena V

AU - Kolesnikova, Tatiana O

AU - Strekalova, Tatiana

AU - Kalueff, Allan V

N1 - Publisher Copyright: © 2022 Elsevier B.V.

PY - 2022/7/26

Y1 - 2022/7/26

N2 - Depression is a widespread and severely debilitating neuropsychiatric disorder whose key clinical symptoms include low mood, anhedonia and despair (the inability or unwillingness to overcome stressors). Experimental animal models are widely used to improve our mechanistic understanding of depression pathogenesis, and to develop novel antidepressant therapies. In rodents, various experimental models of 'behavioral despair' have already been developed and rigorously validated. Complementing rodent studies, the zebrafish (Danio rerio) is emerging as a powerful model organism to assess pathobiological mechanisms of depression and other related affective disorders. Here, we critically discuss the developing potential and important translational implications of zebrafish models for studying despair and its mechanisms, and the utility of such aquatic models for antidepressant drug screening.

AB - Depression is a widespread and severely debilitating neuropsychiatric disorder whose key clinical symptoms include low mood, anhedonia and despair (the inability or unwillingness to overcome stressors). Experimental animal models are widely used to improve our mechanistic understanding of depression pathogenesis, and to develop novel antidepressant therapies. In rodents, various experimental models of 'behavioral despair' have already been developed and rigorously validated. Complementing rodent studies, the zebrafish (Danio rerio) is emerging as a powerful model organism to assess pathobiological mechanisms of depression and other related affective disorders. Here, we critically discuss the developing potential and important translational implications of zebrafish models for studying despair and its mechanisms, and the utility of such aquatic models for antidepressant drug screening.

KW - Animal models

KW - Antidepressant

KW - Behavior

KW - Despair

KW - Zebrafish

UR - http://www.scopus.com/inward/record.url?scp=85130968900&partnerID=8YFLogxK

UR - https://www.mendeley.com/catalogue/d6cd9d26-344d-3564-989d-e270b1ea40ec/

U2 - 10.1016/j.bbr.2022.113906

DO - 10.1016/j.bbr.2022.113906

M3 - Review article

C2 - 35489477

VL - 430

JO - Behavioural Brain Research

JF - Behavioural Brain Research

SN - 0166-4328

M1 - 113906

ER -

ID: 95285084