Research output: Contribution to journal › Review article › peer-review
Towards translational modeling of behavioral despair and its treatment in zebrafish. / Kositsyn, Yuriy M H B; Volgin, Andrew D; de Abreu, Murilo S; Demin, Konstantin A; Zabegalov, Konstantin N; Maslov, Gleb O; Petersen, Elena V; Kolesnikova, Tatiana O; Strekalova, Tatiana; Kalueff, Allan V.
In: Behavioural Brain Research, Vol. 430, 113906, 26.07.2022.Research output: Contribution to journal › Review article › peer-review
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TY - JOUR
T1 - Towards translational modeling of behavioral despair and its treatment in zebrafish
AU - Kositsyn, Yuriy M H B
AU - Volgin, Andrew D
AU - de Abreu, Murilo S
AU - Demin, Konstantin A
AU - Zabegalov, Konstantin N
AU - Maslov, Gleb O
AU - Petersen, Elena V
AU - Kolesnikova, Tatiana O
AU - Strekalova, Tatiana
AU - Kalueff, Allan V
N1 - Publisher Copyright: © 2022 Elsevier B.V.
PY - 2022/7/26
Y1 - 2022/7/26
N2 - Depression is a widespread and severely debilitating neuropsychiatric disorder whose key clinical symptoms include low mood, anhedonia and despair (the inability or unwillingness to overcome stressors). Experimental animal models are widely used to improve our mechanistic understanding of depression pathogenesis, and to develop novel antidepressant therapies. In rodents, various experimental models of 'behavioral despair' have already been developed and rigorously validated. Complementing rodent studies, the zebrafish (Danio rerio) is emerging as a powerful model organism to assess pathobiological mechanisms of depression and other related affective disorders. Here, we critically discuss the developing potential and important translational implications of zebrafish models for studying despair and its mechanisms, and the utility of such aquatic models for antidepressant drug screening.
AB - Depression is a widespread and severely debilitating neuropsychiatric disorder whose key clinical symptoms include low mood, anhedonia and despair (the inability or unwillingness to overcome stressors). Experimental animal models are widely used to improve our mechanistic understanding of depression pathogenesis, and to develop novel antidepressant therapies. In rodents, various experimental models of 'behavioral despair' have already been developed and rigorously validated. Complementing rodent studies, the zebrafish (Danio rerio) is emerging as a powerful model organism to assess pathobiological mechanisms of depression and other related affective disorders. Here, we critically discuss the developing potential and important translational implications of zebrafish models for studying despair and its mechanisms, and the utility of such aquatic models for antidepressant drug screening.
KW - Animal models
KW - Antidepressant
KW - Behavior
KW - Despair
KW - Zebrafish
UR - http://www.scopus.com/inward/record.url?scp=85130968900&partnerID=8YFLogxK
UR - https://www.mendeley.com/catalogue/d6cd9d26-344d-3564-989d-e270b1ea40ec/
U2 - 10.1016/j.bbr.2022.113906
DO - 10.1016/j.bbr.2022.113906
M3 - Review article
C2 - 35489477
VL - 430
JO - Behavioural Brain Research
JF - Behavioural Brain Research
SN - 0166-4328
M1 - 113906
ER -
ID: 95285084