Research output: Contribution to conference › Abstract › peer-review
Towards the zebrafish-based models for personalized psychiatry - insights from individual, strain and gender differences, and modeling gene x environment interactions. / Волгин, Андрей; Яковлев, Олег; Демин, Константин Андреевич; de Abreu, Murilo; Алексеева, Полина; Friend, Ashton; Амстиславская, Тамара; Калуев, Алан Валерьевич.
2018. 45 Abstract from Stress and Behavior, St.Petersburg, Russian Federation.Research output: Contribution to conference › Abstract › peer-review
}
TY - CONF
T1 - Towards the zebrafish-based models for personalized psychiatry - insights from individual, strain and gender differences, and modeling gene x environment interactions
AU - Волгин, Андрей
AU - Яковлев, Олег
AU - Демин, Константин Андреевич
AU - de Abreu, Murilo
AU - Алексеева, Полина
AU - Friend, Ashton
AU - Амстиславская, Тамара
AU - Калуев, Алан Валерьевич
N1 - Conference code: 25
PY - 2018/5/16
Y1 - 2018/5/16
N2 - Currently becoming widely recognized, personalized psychiatry focuses on patients’ unique physiological and genetic profiles to best tailor their therapy. However, the role of individual differences, as well as genetic and environmental factors, in human psychiatric disorders remain poorly understood. Animal experimental models are a valuable tool to improve our understanding of disease pathophysiology and its molecular mechanisms. Due to high reproduction capability, fully sequenced genome, easy gene editing and high physiological homology with humans, zebrafish (Danio rerio) are emerging as a novel powerful model in biomedicine. Mounting evidence support zebrafish as a useful model organism in CNS research. Robustly expressed in these fish, individual, strain and sex differences shape their CNS responses to genetic, environmental and pharmacological manipulations. Here, we discuss zebrafish as a promising translational tool to further advance patient-centered personalized psychiatry.
AB - Currently becoming widely recognized, personalized psychiatry focuses on patients’ unique physiological and genetic profiles to best tailor their therapy. However, the role of individual differences, as well as genetic and environmental factors, in human psychiatric disorders remain poorly understood. Animal experimental models are a valuable tool to improve our understanding of disease pathophysiology and its molecular mechanisms. Due to high reproduction capability, fully sequenced genome, easy gene editing and high physiological homology with humans, zebrafish (Danio rerio) are emerging as a novel powerful model in biomedicine. Mounting evidence support zebrafish as a useful model organism in CNS research. Robustly expressed in these fish, individual, strain and sex differences shape their CNS responses to genetic, environmental and pharmacological manipulations. Here, we discuss zebrafish as a promising translational tool to further advance patient-centered personalized psychiatry.
M3 - Abstract
SP - 45
T2 - Stress and Behavior
Y2 - 16 May 2018 through 19 May 2018
ER -
ID: 33279497