Towards Novel Potential Molecular Targets for Antidepressant and Antipsychotic Pharmacotherapies

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Towards Novel Potential Molecular Targets for Antidepressant and Antipsychotic Pharmacotherapies. / Kositsyn , Yuriy M. ; de Abreu, Murilo; Kolesnikova , Tatiana O.; Lagunin, Aleхey A.; Poroikov, Vladimir V.; Harutyunyan, Hasmik S. ; Yenkoyan, Konstantin; Kalueff , Allan V. .

In: International Journal of Molecular Sciences, Vol. 24, No. 11, 9482, 30.05.2023.

Research output: Contribution to journal › Review article › peer-review

Author

Kositsyn , Yuriy M. ; de Abreu, Murilo ; Kolesnikova , Tatiana O. ; Lagunin, Aleхey A. ; Poroikov, Vladimir V. ; Harutyunyan, Hasmik S. ; Yenkoyan, Konstantin ; Kalueff , Allan V. . / Towards Novel Potential Molecular Targets for Antidepressant and Antipsychotic Pharmacotherapies. In: International Journal of Molecular Sciences. 2023 ; Vol. 24, No. 11.

BibTeX

@article{d33b8bbe6afe4ea8a27f2fb68d38578c,

title = "Towards Novel Potential Molecular Targets for Antidepressant and Antipsychotic Pharmacotherapies",

abstract = "Depression and schizophrenia are two highly prevalent and severely debilitating neuropsychiatric disorders. Both conventional antidepressant and antipsychotic pharmacotherapies are often inefficient clinically, causing multiple side effects and serious patient compliance problems. Collectively, this calls for the development of novel drug targets for treating depressed and schizophrenic patients. Here, we discuss recent translational advances, research tools and approaches, aiming to facilitate innovative drug discovery in this field. Providing a comprehensive overview of current antidepressants and antipsychotic drugs, we also outline potential novel molecular targets for treating depression and schizophrenia. We also critically evaluate multiple translational challenges and summarize various open questions, in order to foster further integrative cross-discipline research into antidepressant and antipsychotic drug development.",

keywords = "depression, psychosis, schizophrenia, pathogenesis, novel molecular targets, Humans, Antidepressive Agents/pharmacology, Schizophrenia/drug therapy, Antipsychotic Agents/adverse effects",

author = "Kositsyn, {Yuriy M.} and {de Abreu}, Murilo and Kolesnikova, {Tatiana O.} and Lagunin, {Aleхey A.} and Poroikov, {Vladimir V.} and Harutyunyan, {Hasmik S.} and Konstantin Yenkoyan and Kalueff, {Allan V.}",

note = "Kositsyn, Y.M.; de Abreu, M.S.; Kolesnikova, T.O.; Lagunin, A.A.; Poroikov, V.V.; Harutyunyan, H.S.; Yenkoyan, K.B.; Kalueff, A.V. Towards Novel Potential Molecular Targets for Antidepressant and Antipsychotic Pharmacotherapies. Int. J. Mol. Sci. 2023, 24, 9482. https://doi.org/10.3390/ijms24119482",

year = "2023",

month = may,

day = "30",

doi = "10.3390/ijms24119482",

language = "English",

volume = "24",

journal = "International Journal of Molecular Sciences",

issn = "1422-0067",

publisher = "MDPI AG",

number = "11",

}

RIS

TY - JOUR

T1 - Towards Novel Potential Molecular Targets for Antidepressant and Antipsychotic Pharmacotherapies

AU - Kositsyn , Yuriy M.

AU - de Abreu, Murilo

AU - Kolesnikova , Tatiana O.

AU - Lagunin, Aleхey A.

AU - Poroikov, Vladimir V.

AU - Harutyunyan, Hasmik S.

AU - Yenkoyan, Konstantin

AU - Kalueff , Allan V.

N1 - Kositsyn, Y.M.; de Abreu, M.S.; Kolesnikova, T.O.; Lagunin, A.A.; Poroikov, V.V.; Harutyunyan, H.S.; Yenkoyan, K.B.; Kalueff, A.V. Towards Novel Potential Molecular Targets for Antidepressant and Antipsychotic Pharmacotherapies. Int. J. Mol. Sci. 2023, 24, 9482. https://doi.org/10.3390/ijms24119482

PY - 2023/5/30

Y1 - 2023/5/30

N2 - Depression and schizophrenia are two highly prevalent and severely debilitating neuropsychiatric disorders. Both conventional antidepressant and antipsychotic pharmacotherapies are often inefficient clinically, causing multiple side effects and serious patient compliance problems. Collectively, this calls for the development of novel drug targets for treating depressed and schizophrenic patients. Here, we discuss recent translational advances, research tools and approaches, aiming to facilitate innovative drug discovery in this field. Providing a comprehensive overview of current antidepressants and antipsychotic drugs, we also outline potential novel molecular targets for treating depression and schizophrenia. We also critically evaluate multiple translational challenges and summarize various open questions, in order to foster further integrative cross-discipline research into antidepressant and antipsychotic drug development.

AB - Depression and schizophrenia are two highly prevalent and severely debilitating neuropsychiatric disorders. Both conventional antidepressant and antipsychotic pharmacotherapies are often inefficient clinically, causing multiple side effects and serious patient compliance problems. Collectively, this calls for the development of novel drug targets for treating depressed and schizophrenic patients. Here, we discuss recent translational advances, research tools and approaches, aiming to facilitate innovative drug discovery in this field. Providing a comprehensive overview of current antidepressants and antipsychotic drugs, we also outline potential novel molecular targets for treating depression and schizophrenia. We also critically evaluate multiple translational challenges and summarize various open questions, in order to foster further integrative cross-discipline research into antidepressant and antipsychotic drug development.

KW - depression

KW - psychosis

KW - schizophrenia

KW - pathogenesis

KW - novel molecular targets

KW - Humans

KW - Antidepressive Agents/pharmacology

KW - Schizophrenia/drug therapy

KW - Antipsychotic Agents/adverse effects

UR - https://www.mendeley.com/catalogue/268f142f-ef1a-3442-bb41-892cd55fdc74/

U2 - 10.3390/ijms24119482

DO - 10.3390/ijms24119482

M3 - Review article

C2 - 37298431

VL - 24

JO - International Journal of Molecular Sciences

JF - International Journal of Molecular Sciences

SN - 1422-0067

IS - 11

M1 - 9482

ER -

ID: 106448402