Research output: Contribution to journal › Article › peer-review
Towards modeling anhedonia and its treatment in zebrafish. / de Abreu, M.S.; Costa, Fabiano V.; Giacomini, Ana C.V.V.; Demin, Konstantin A. ; Zabegalov, Konstantin N. ; Maslov, Gleb O. ; Kositsyn, Yuriy M. ; Petersen, Elena V.; Strekalova, Tatyana; Rosemberg, Denis B.; Kalueff, Allan V. .
In: International Journal of Neuropsychopharmacology, 12.2021.Research output: Contribution to journal › Article › peer-review
}
TY - JOUR
T1 - Towards modeling anhedonia and its treatment in zebrafish
AU - de Abreu, M.S.
AU - Costa, Fabiano V.
AU - Giacomini, Ana C.V.V.
AU - Demin, Konstantin A.
AU - Zabegalov, Konstantin N.
AU - Maslov, Gleb O.
AU - Kositsyn, Yuriy M.
AU - Petersen, Elena V.
AU - Strekalova, Tatyana
AU - Rosemberg, Denis B.
AU - Kalueff, Allan V.
N1 - S de Abreu M, Costa F, Giacomini ACVV, Demin KA, Zabegalov KN, Maslov GO, Kositsyn YM, Petersen EV, Strekalova T, Rosemberg DB, Kalueff AV. Towards modeling anhedonia and its treatment in zebrafish. Int J Neuropsychopharmacol. 2021 Dec 16:pyab092. doi: 10.1093/ijnp/pyab092. Epub ahead of print. PMID: 34918075.
PY - 2021/12
Y1 - 2021/12
N2 - Mood disorders, especially depression, are a major cause of human disability. The loss of pleasure (anhedonia) is a common, severely debilitating symptom of clinical depression. Experimental animal models are widely used to better understand depression pathogenesis, and to develop novel antidepressant therapies. In rodents, various experimental models of anhedonia have already been developed and validated. Complementing rodent studies, the zebrafish (Danio rerio) is emerging as a powerful model organism to assess pathobiological mechanisms of affective disorders. Here, we critically discuss the potential of zebrafish for modeling anhedonia and studying its molecular mechanisms and translational implications.
AB - Mood disorders, especially depression, are a major cause of human disability. The loss of pleasure (anhedonia) is a common, severely debilitating symptom of clinical depression. Experimental animal models are widely used to better understand depression pathogenesis, and to develop novel antidepressant therapies. In rodents, various experimental models of anhedonia have already been developed and validated. Complementing rodent studies, the zebrafish (Danio rerio) is emerging as a powerful model organism to assess pathobiological mechanisms of affective disorders. Here, we critically discuss the potential of zebrafish for modeling anhedonia and studying its molecular mechanisms and translational implications.
KW - anhedonia
KW - animal models
KW - antidepressant
KW - behavior
KW - zebrafish
UR - https://pubmed.ncbi.nlm.nih.gov/34918075/
M3 - Article
JO - International Journal of Neuropsychopharmacology
JF - International Journal of Neuropsychopharmacology
SN - 1461-1457
M1 - 34918075
ER -
ID: 89531578