Thin Films of Lanthanide Stearates as Modifiers of the Q-Sense Device Sensor for Studying Insulin Adsorption

Standard

Thin Films of Lanthanide Stearates as Modifiers of the Q-Sense Device Sensor for Studying Insulin Adsorption. / Ладикан, Ольга Владимировна ; Силявка, Елена Сергеевна ; Mitrofanov, Andrey ; Лаптенкова, Анастасия Владимировна; Шиловских, Владимир Владимирович; Колоницкий, Петр Дмитриевич; Иванов, Никита Сергеевич ; Ремезов, Андрей Владимирович ; Федорова, Анна Викторовна ; Хрипун, Василий Дмитриевич ; Пестова, Ольга Николаевна; Подольская, Екатерина Петровна; Суходолов, Николай Геннадьевич ; Селютин, Артем Александрович.

In: ACS Omega, Vol. 7, No. 29, 26.07.2022, p. 24973-24981.

Research output: Contribution to journal › Article › peer-review

BibTeX

@article{bd3b2ab057b04cacad2f7a603b38e4b6,

title = "Thin Films of Lanthanide Stearates as Modifiers of the Q-Sense Device Sensor for Studying Insulin Adsorption",

abstract = "This article presents new possibilities of using thin films of lanthanide stearates as sorbent materials. Modification of the Q-sense device resonator with monolayers of lanthanide stearates by the Langmuir-Schaeffer method made it possible to study the process of insulin protein adsorption on the surface of new thin-film sorbents. The resulting films were also characterized by compression isotherms, chemical analysis, scanning electron microscopy, and mass spectrometry. The transition of stearic acid to salt was recorded by IR spectroscopy. Using the LDI MS method, the main component of thin films, lanthanide distearate, was established. The presence of Eu 2+ in thin films was revealed. In the case of europium stearate, the maximum value of insulin adsorption was obtained, -1.67·10 -10 mole/cm 2. The findings suggest the possibility of using thin films of lanthanide stearates as a sorption material for the proteomics determination of the quantitative protein content in complex fluid systems by specific adsorption on modified surfaces and isolation of such proteins from complex mixtures. ",

author = "Ладикан, {Ольга Владимировна} and Силявка, {Елена Сергеевна} and Andrey Mitrofanov and Лаптенкова, {Анастасия Владимировна} and Шиловских, {Владимир Владимирович} and Колоницкий, {Петр Дмитриевич} and Иванов, {Никита Сергеевич} and Ремезов, {Андрей Владимирович} and Федорова, {Анна Викторовна} and Хрипун, {Василий Дмитриевич} and Пестова, {Ольга Николаевна} and Подольская, {Екатерина Петровна} and Суходолов, {Николай Геннадьевич} and Селютин, {Артем Александрович}",

year = "2022",

month = jul,

day = "26",

doi = "10.1021/acsomega.1c07300",

language = "English",

volume = "7",

pages = "24973--24981",

journal = "ACS Omega",

issn = "2470-1343",

publisher = "American Chemical Society",

number = "29",

}

RIS

TY - JOUR

T1 - Thin Films of Lanthanide Stearates as Modifiers of the Q-Sense Device Sensor for Studying Insulin Adsorption

AU - Ладикан, Ольга Владимировна

AU - Силявка, Елена Сергеевна

AU - Mitrofanov, Andrey

AU - Лаптенкова, Анастасия Владимировна

AU - Шиловских, Владимир Владимирович

AU - Колоницкий, Петр Дмитриевич

AU - Иванов, Никита Сергеевич

AU - Ремезов, Андрей Владимирович

AU - Федорова, Анна Викторовна

AU - Хрипун, Василий Дмитриевич

AU - Пестова, Ольга Николаевна

AU - Подольская, Екатерина Петровна

AU - Суходолов, Николай Геннадьевич

AU - Селютин, Артем Александрович

PY - 2022/7/26

Y1 - 2022/7/26

N2 - This article presents new possibilities of using thin films of lanthanide stearates as sorbent materials. Modification of the Q-sense device resonator with monolayers of lanthanide stearates by the Langmuir-Schaeffer method made it possible to study the process of insulin protein adsorption on the surface of new thin-film sorbents. The resulting films were also characterized by compression isotherms, chemical analysis, scanning electron microscopy, and mass spectrometry. The transition of stearic acid to salt was recorded by IR spectroscopy. Using the LDI MS method, the main component of thin films, lanthanide distearate, was established. The presence of Eu 2+ in thin films was revealed. In the case of europium stearate, the maximum value of insulin adsorption was obtained, -1.67·10 -10 mole/cm 2. The findings suggest the possibility of using thin films of lanthanide stearates as a sorption material for the proteomics determination of the quantitative protein content in complex fluid systems by specific adsorption on modified surfaces and isolation of such proteins from complex mixtures.

AB - This article presents new possibilities of using thin films of lanthanide stearates as sorbent materials. Modification of the Q-sense device resonator with monolayers of lanthanide stearates by the Langmuir-Schaeffer method made it possible to study the process of insulin protein adsorption on the surface of new thin-film sorbents. The resulting films were also characterized by compression isotherms, chemical analysis, scanning electron microscopy, and mass spectrometry. The transition of stearic acid to salt was recorded by IR spectroscopy. Using the LDI MS method, the main component of thin films, lanthanide distearate, was established. The presence of Eu 2+ in thin films was revealed. In the case of europium stearate, the maximum value of insulin adsorption was obtained, -1.67·10 -10 mole/cm 2. The findings suggest the possibility of using thin films of lanthanide stearates as a sorption material for the proteomics determination of the quantitative protein content in complex fluid systems by specific adsorption on modified surfaces and isolation of such proteins from complex mixtures.

UR - http://www.scopus.com/inward/record.url?scp=85135688011&partnerID=8YFLogxK

U2 - 10.1021/acsomega.1c07300

DO - 10.1021/acsomega.1c07300

M3 - Article

C2 - 35910105

VL - 7

SP - 24973

EP - 24981

JO - ACS Omega

JF - ACS Omega

SN - 2470-1343

IS - 29

ER -

ID: 97127530