The paper presents experimental and DFT simulated data on temperature dependence of heat capacity for C₆₀-L-arginine derivative. Smoothed C_p,m ^∘Tvalues in the temperature range from T → 0 K to 320 K are presented along with the values of standard thermodynamic functions: S_m ^°, [H_m ^∘T-H_m ^∘0] and [Φ_m ^∘T-Φ_m ^∘0]. In addition, the molar third law entropy and the molar formation entropy of the C₆₀-L-arginine derivative in crystalline state at T = 298.15 K are calculated. The data on complex thermal analysis reveal that the C₆₀-L-arginine derivative is stable up to 340 K. Further increasing of temperature leads to destruction of L-arginine groups and oxidation of fullerene core.