Research output: Contribution to journal › Article › peer-review
Thermochemical analysis of intermolecular interactions of L-carnosine with isonicotinic acid in aqueous solutions. / Krutova, O. N.; Usacheva, T. R.; Myshenkov, M. S.; Niccoli, M.; Giancola, C.
In: Journal of Thermal Analysis and Calorimetry, Vol. 146, 10.07.2021, p. 993-999.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - Thermochemical analysis of intermolecular interactions of L-carnosine with isonicotinic acid in aqueous solutions
AU - Krutova, O. N.
AU - Usacheva, T. R.
AU - Myshenkov, M. S.
AU - Niccoli, M.
AU - Giancola, C.
N1 - Publisher Copyright: © 2021, Akadémiai Kiadó, Budapest, Hungary.
PY - 2021/7/10
Y1 - 2021/7/10
N2 - Investigation of the interactions between pyridine derivatives and model compounds of protein, as dipeptides and oligopeptides, is of special interest for pharmaceutical applications. Studies on physicochemical properties of their aqueous solutions play key role in understanding the nature of molecular interactions in liquid mixtures. Here the calorimetric method was used to measure the enthalpy of mixing in aqueous solutions of the dipeptide L-carnosine with the drug isonicotinic acid. The data were analyzed based on the McMillan–Mayer theory to obtain the cross-pair interaction coefficient, hxy, that indicates relatively strong interactions with predominant hydrophilic specific interactions.
AB - Investigation of the interactions between pyridine derivatives and model compounds of protein, as dipeptides and oligopeptides, is of special interest for pharmaceutical applications. Studies on physicochemical properties of their aqueous solutions play key role in understanding the nature of molecular interactions in liquid mixtures. Here the calorimetric method was used to measure the enthalpy of mixing in aqueous solutions of the dipeptide L-carnosine with the drug isonicotinic acid. The data were analyzed based on the McMillan–Mayer theory to obtain the cross-pair interaction coefficient, hxy, that indicates relatively strong interactions with predominant hydrophilic specific interactions.
KW - калориметрия
KW - связывание молекул
KW - калориметрия титрования
KW - Thermodynamics
KW - Water solutions
KW - Isothermal titration calorimeter
KW - Enthalpy
KW - Isonicotinic acid
KW - L-carnosine
KW - ALPHA-AMINO-ACIDS
KW - EXCESS-ENTHALPIES
KW - TEMPERATURE
KW - DEPENDENCE
KW - CATARACT
KW - WATER
UR - http://www.scopus.com/inward/record.url?scp=85110459559&partnerID=8YFLogxK
U2 - 10.1007/s10973-021-10982-1
DO - 10.1007/s10973-021-10982-1
M3 - Article
AN - SCOPUS:85110459559
VL - 146
SP - 993
EP - 999
JO - Journal of Thermal Analysis and Calorimetry
JF - Journal of Thermal Analysis and Calorimetry
SN - 1388-6150
ER -
ID: 87280231