Standard

The Vertebrate TLR Supergene Family Evolved Dynamically by Gene Gain/Loss and Positive Selection Revealing a Host–Pathogen Arms Race in Birds. / Khan, Imran ; Maldonado, Emanuel; Silva, Liliana; Almeida, D.; Johnson, Warren E.; O’Brien, Stephen J. ; Zhang, Guojie; Jarvis, Erich D.; Gilbert, M. Thomas P.; Antunes, A.

In: Diversity, Vol. 11, No. 8, 131, 08.2019.

Research output: Contribution to journal › Article › peer-review

Harvard

Khan, I, Maldonado, E, Silva, L, Almeida, D, Johnson, WE, O’Brien, SJ, Zhang, G, Jarvis, ED, Gilbert, MTP & Antunes, A 2019, 'The Vertebrate TLR Supergene Family Evolved Dynamically by Gene Gain/Loss and Positive Selection Revealing a Host–Pathogen Arms Race in Birds', Diversity, vol. 11, no. 8, 131. https://doi.org/10.3390/d11080131

APA

Khan, I., Maldonado, E., Silva, L., Almeida, D., Johnson, W. E., O’Brien, S. J., Zhang, G., Jarvis, E. D., Gilbert, M. T. P., & Antunes, A. (2019). The Vertebrate TLR Supergene Family Evolved Dynamically by Gene Gain/Loss and Positive Selection Revealing a Host–Pathogen Arms Race in Birds. Diversity, 11(8), [131]. https://doi.org/10.3390/d11080131

Vancouver

Khan I, Maldonado E, Silva L, Almeida D, Johnson WE, O’Brien SJ et al. The Vertebrate TLR Supergene Family Evolved Dynamically by Gene Gain/Loss and Positive Selection Revealing a Host–Pathogen Arms Race in Birds. Diversity. 2019 Aug;11(8). 131. https://doi.org/10.3390/d11080131

Author

Khan, Imran ; Maldonado, Emanuel ; Silva, Liliana ; Almeida, D. ; Johnson, Warren E. ; O’Brien, Stephen J. ; Zhang, Guojie ; Jarvis, Erich D. ; Gilbert, M. Thomas P. ; Antunes, A. / The Vertebrate TLR Supergene Family Evolved Dynamically by Gene Gain/Loss and Positive Selection Revealing a Host–Pathogen Arms Race in Birds. In: Diversity. 2019 ; Vol. 11, No. 8.

BibTeX

@article{1cc1d6be3989428a88905674101246a6,
title = "The Vertebrate TLR Supergene Family Evolved Dynamically by Gene Gain/Loss and Positive Selection Revealing a Host–Pathogen Arms Race in Birds",
abstract = "The vertebrate toll-like receptor (TLRs) supergene family is a first-line immune defense against viral and non-viral pathogens. Here, comparative evolutionary-genomics of 79 vertebrate species (8 mammals, 48 birds, 11 reptiles, 1 amphibian, and 11 fishes) revealed differential gain/loss of 26 TLRs, including 6 (TLR3, TLR7, TLR8, TLR14, TLR21, and TLR22) that originated early in vertebrate evolution before the diversification of Agnatha and Gnathostomata. Subsequent dynamic gene gain/loss led to lineage-specific diversification with TLR repertoires ranging from 8 subfamilies in birds to 20 in fishes. Lineage-specific loss of TLR8-9 and TLR13 in birds and gains of TLR6 and TLR10-12 in mammals and TLR19-20 and TLR23-27 in fishes. Among avian species, 5–10% of the sites were under positive selection (PS) (omega 1.5–2.5) with radical amino-acid changes likely affecting TLR structure/functionality. In non-viral TLR4 the 20 PS sites (posterior probability PP > 0.99) likely increased ability to cope with diversified ligands (e.g., lipopolysaccharide and lipoteichoic). For viral TLR7, 23 PS sites (PP > 0.99) possibly improved recognition of highly variable viral ssRNAs. Rapid evolution of the TLR supergene family reflects the host–pathogen arms race and the coevolution of ligands/receptors, which follows the premise that birds have been important vectors of zoonotic pathogens and reservoirs for viruses.",
keywords = "Биоинформатика, gene gain, gene loss, vertebrates, toll-like receptors, immune response, host–pathogen, positive selection, Gene loss, Host-pathogen, Gene gain, Immune response, Positive selection, Vertebrates, Toll-like receptors",
author = "Imran Khan and Emanuel Maldonado and Liliana Silva and D. Almeida and Johnson, {Warren E.} and O{\textquoteright}Brien, {Stephen J.} and Guojie Zhang and Jarvis, {Erich D.} and Gilbert, {M. Thomas P.} and A. Antunes",
year = "2019",
month = aug,
doi = "10.3390/d11080131",
language = "English",
volume = "11",
journal = "Diversity",
issn = "1424-2818",
publisher = "MDPI AG",
number = "8",

}

RIS

TY - JOUR

T1 - The Vertebrate TLR Supergene Family Evolved Dynamically by Gene Gain/Loss and Positive Selection Revealing a Host–Pathogen Arms Race in Birds

AU - Khan, Imran

AU - Maldonado, Emanuel

AU - Silva, Liliana

AU - Almeida, D.

AU - Johnson, Warren E.

AU - O’Brien, Stephen J.

AU - Zhang, Guojie

AU - Jarvis, Erich D.

AU - Gilbert, M. Thomas P.

AU - Antunes, A.

PY - 2019/8

Y1 - 2019/8

N2 - The vertebrate toll-like receptor (TLRs) supergene family is a first-line immune defense against viral and non-viral pathogens. Here, comparative evolutionary-genomics of 79 vertebrate species (8 mammals, 48 birds, 11 reptiles, 1 amphibian, and 11 fishes) revealed differential gain/loss of 26 TLRs, including 6 (TLR3, TLR7, TLR8, TLR14, TLR21, and TLR22) that originated early in vertebrate evolution before the diversification of Agnatha and Gnathostomata. Subsequent dynamic gene gain/loss led to lineage-specific diversification with TLR repertoires ranging from 8 subfamilies in birds to 20 in fishes. Lineage-specific loss of TLR8-9 and TLR13 in birds and gains of TLR6 and TLR10-12 in mammals and TLR19-20 and TLR23-27 in fishes. Among avian species, 5–10% of the sites were under positive selection (PS) (omega 1.5–2.5) with radical amino-acid changes likely affecting TLR structure/functionality. In non-viral TLR4 the 20 PS sites (posterior probability PP > 0.99) likely increased ability to cope with diversified ligands (e.g., lipopolysaccharide and lipoteichoic). For viral TLR7, 23 PS sites (PP > 0.99) possibly improved recognition of highly variable viral ssRNAs. Rapid evolution of the TLR supergene family reflects the host–pathogen arms race and the coevolution of ligands/receptors, which follows the premise that birds have been important vectors of zoonotic pathogens and reservoirs for viruses.

AB - The vertebrate toll-like receptor (TLRs) supergene family is a first-line immune defense against viral and non-viral pathogens. Here, comparative evolutionary-genomics of 79 vertebrate species (8 mammals, 48 birds, 11 reptiles, 1 amphibian, and 11 fishes) revealed differential gain/loss of 26 TLRs, including 6 (TLR3, TLR7, TLR8, TLR14, TLR21, and TLR22) that originated early in vertebrate evolution before the diversification of Agnatha and Gnathostomata. Subsequent dynamic gene gain/loss led to lineage-specific diversification with TLR repertoires ranging from 8 subfamilies in birds to 20 in fishes. Lineage-specific loss of TLR8-9 and TLR13 in birds and gains of TLR6 and TLR10-12 in mammals and TLR19-20 and TLR23-27 in fishes. Among avian species, 5–10% of the sites were under positive selection (PS) (omega 1.5–2.5) with radical amino-acid changes likely affecting TLR structure/functionality. In non-viral TLR4 the 20 PS sites (posterior probability PP > 0.99) likely increased ability to cope with diversified ligands (e.g., lipopolysaccharide and lipoteichoic). For viral TLR7, 23 PS sites (PP > 0.99) possibly improved recognition of highly variable viral ssRNAs. Rapid evolution of the TLR supergene family reflects the host–pathogen arms race and the coevolution of ligands/receptors, which follows the premise that birds have been important vectors of zoonotic pathogens and reservoirs for viruses.

KW - Биоинформатика

KW - gene gain

KW - gene loss

KW - vertebrates

KW - toll-like receptors

KW - immune response

KW - host–pathogen

KW - positive selection

KW - Gene loss

KW - Host-pathogen

KW - Gene gain

KW - Immune response

KW - Positive selection

KW - Vertebrates

KW - Toll-like receptors

UR - http://www.mendeley.com/research/vertebrate-tlr-supergene-family-evolved-dynamically-gene-gainloss-positive-selection-revealing-hostp

U2 - 10.3390/d11080131

DO - 10.3390/d11080131

M3 - Article

VL - 11

JO - Diversity

JF - Diversity

SN - 1424-2818

IS - 8

M1 - 131

ER -

ID: 49514474