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The uteroplacental contact zone cytokine influence on NK cell cytotoxicity to trophoblasts. / Bazhenov, Dmitriy; Mikhailova, Valentina; Nikolaenkov, Igor; Markova, Kseniya; Salloum, Zeina; Kogan, Igor; Gzgzyan, Aleksandr; Selkov, Sergey; Sokolov, Dmitriy.

In: Gynecological Endocrinology, Vol. 36, No. S1, 2020, p. 1-6.

Research output: Contribution to journalArticlepeer-review

Harvard

Bazhenov, D, Mikhailova, V, Nikolaenkov, I, Markova, K, Salloum, Z, Kogan, I, Gzgzyan, A, Selkov, S & Sokolov, D 2020, 'The uteroplacental contact zone cytokine influence on NK cell cytotoxicity to trophoblasts', Gynecological Endocrinology, vol. 36, no. S1, pp. 1-6. https://doi.org/10.1080/09513590.2020.1816715

APA

Bazhenov, D., Mikhailova, V., Nikolaenkov, I., Markova, K., Salloum, Z., Kogan, I., Gzgzyan, A., Selkov, S., & Sokolov, D. (2020). The uteroplacental contact zone cytokine influence on NK cell cytotoxicity to trophoblasts. Gynecological Endocrinology, 36(S1), 1-6. https://doi.org/10.1080/09513590.2020.1816715

Vancouver

Bazhenov D, Mikhailova V, Nikolaenkov I, Markova K, Salloum Z, Kogan I et al. The uteroplacental contact zone cytokine influence on NK cell cytotoxicity to trophoblasts. Gynecological Endocrinology. 2020;36(S1):1-6. https://doi.org/10.1080/09513590.2020.1816715

Author

Bazhenov, Dmitriy ; Mikhailova, Valentina ; Nikolaenkov, Igor ; Markova, Kseniya ; Salloum, Zeina ; Kogan, Igor ; Gzgzyan, Aleksandr ; Selkov, Sergey ; Sokolov, Dmitriy. / The uteroplacental contact zone cytokine influence on NK cell cytotoxicity to trophoblasts. In: Gynecological Endocrinology. 2020 ; Vol. 36, No. S1. pp. 1-6.

BibTeX

@article{37cf2924a9224ea3ad3b1b293099bd1a,
title = "The uteroplacental contact zone cytokine influence on NK cell cytotoxicity to trophoblasts",
abstract = "Objective: The present study was to estimate the role of cytokines for trophoblast death in NK cells presence. Methods: This study involves assessment of NK-92 line NK cell cytotoxic activity against JEG-3 line cells, in presence of cytokines. We also assessed the effect of secretory placenta products on NK cell cytotoxic activity toward JEG-3 line cells. Results: Uteroplacental contact zone cytokines are able to enhance trophoblast mortality both by themselves in case of IL-1β, IL-6, IFNγ, IL-4, TGFβ, bFGF, and also through increasing the cytotoxic potential of NK cells in case of IL-1β, IFNγ, IL-8, TGFβ, and GM-CSF. PLGF decreases NK cell cytotoxicity for trophoblasts. Secretory products of first trimester placenta enhance NK cell cytotoxic potential for trophoblasts. Conclusions: Cytokines of the uteroplacental contact zone can appear a mechanism ensuring trophoblast mortality dynamics throughout pregnancy.",
keywords = "cytokines, cytotoxicity, JEG-3, K562, natural killer cells, placenta, Trophoblast",
author = "Dmitriy Bazhenov and Valentina Mikhailova and Igor Nikolaenkov and Kseniya Markova and Zeina Salloum and Igor Kogan and Aleksandr Gzgzyan and Sergey Selkov and Dmitriy Sokolov",
note = "Funding Information: The study was supported by RFBR under grant No. 20-015-00014 (estimation of cytotoxic activity by flow cytometry); the government program No. ????-?19-119021290116-1 (cell culture) and No. ????-?20-120041390033-4 (method approbation). The participation of D.O.B. was funded by a Presidential Scholarship SP-2836.2018.4. Publisher Copyright: {\textcopyright} 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group on behalf of the UR MED GRUPP (LLC). Copyright: Copyright 2020 Elsevier B.V., All rights reserved.",
year = "2020",
doi = "10.1080/09513590.2020.1816715",
language = "English",
volume = "36",
pages = "1--6",
journal = "Gynecological Endocrinology",
issn = "0951-3590",
publisher = "Taylor & Francis",
number = "S1",

}

RIS

TY - JOUR

T1 - The uteroplacental contact zone cytokine influence on NK cell cytotoxicity to trophoblasts

AU - Bazhenov, Dmitriy

AU - Mikhailova, Valentina

AU - Nikolaenkov, Igor

AU - Markova, Kseniya

AU - Salloum, Zeina

AU - Kogan, Igor

AU - Gzgzyan, Aleksandr

AU - Selkov, Sergey

AU - Sokolov, Dmitriy

N1 - Funding Information: The study was supported by RFBR under grant No. 20-015-00014 (estimation of cytotoxic activity by flow cytometry); the government program No. ????-?19-119021290116-1 (cell culture) and No. ????-?20-120041390033-4 (method approbation). The participation of D.O.B. was funded by a Presidential Scholarship SP-2836.2018.4. Publisher Copyright: © 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group on behalf of the UR MED GRUPP (LLC). Copyright: Copyright 2020 Elsevier B.V., All rights reserved.

PY - 2020

Y1 - 2020

N2 - Objective: The present study was to estimate the role of cytokines for trophoblast death in NK cells presence. Methods: This study involves assessment of NK-92 line NK cell cytotoxic activity against JEG-3 line cells, in presence of cytokines. We also assessed the effect of secretory placenta products on NK cell cytotoxic activity toward JEG-3 line cells. Results: Uteroplacental contact zone cytokines are able to enhance trophoblast mortality both by themselves in case of IL-1β, IL-6, IFNγ, IL-4, TGFβ, bFGF, and also through increasing the cytotoxic potential of NK cells in case of IL-1β, IFNγ, IL-8, TGFβ, and GM-CSF. PLGF decreases NK cell cytotoxicity for trophoblasts. Secretory products of first trimester placenta enhance NK cell cytotoxic potential for trophoblasts. Conclusions: Cytokines of the uteroplacental contact zone can appear a mechanism ensuring trophoblast mortality dynamics throughout pregnancy.

AB - Objective: The present study was to estimate the role of cytokines for trophoblast death in NK cells presence. Methods: This study involves assessment of NK-92 line NK cell cytotoxic activity against JEG-3 line cells, in presence of cytokines. We also assessed the effect of secretory placenta products on NK cell cytotoxic activity toward JEG-3 line cells. Results: Uteroplacental contact zone cytokines are able to enhance trophoblast mortality both by themselves in case of IL-1β, IL-6, IFNγ, IL-4, TGFβ, bFGF, and also through increasing the cytotoxic potential of NK cells in case of IL-1β, IFNγ, IL-8, TGFβ, and GM-CSF. PLGF decreases NK cell cytotoxicity for trophoblasts. Secretory products of first trimester placenta enhance NK cell cytotoxic potential for trophoblasts. Conclusions: Cytokines of the uteroplacental contact zone can appear a mechanism ensuring trophoblast mortality dynamics throughout pregnancy.

KW - cytokines

KW - cytotoxicity

KW - JEG-3

KW - K562

KW - natural killer cells

KW - placenta

KW - Trophoblast

UR - http://www.scopus.com/inward/record.url?scp=85097493910&partnerID=8YFLogxK

U2 - 10.1080/09513590.2020.1816715

DO - 10.1080/09513590.2020.1816715

M3 - Article

C2 - 33305669

AN - SCOPUS:85097493910

VL - 36

SP - 1

EP - 6

JO - Gynecological Endocrinology

JF - Gynecological Endocrinology

SN - 0951-3590

IS - S1

ER -

ID: 74990382