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The Use of Mesenchymal Stem Cells in the Complex Treatment of Kidney Tuberculosis (Experimental Study). / Muraviov, Alexander N. ; Vinogradova, Tatiana I. ; Remezova, Anna N. ; Ariel, Boris M. ; Gorelova, Anna A. ; Orlova , Nadezhda V. ; Yudintceva , Natalia M. ; Esmedliaeva, Diljara S. ; Dyakova , Marina E. ; Dogonadze, Marine Z. ; Zabolotnykh , Natalia V. ; Garapach, Irina A. ; Maslak , Olga S. ; Kirillov, Yuri A. ; Timofeev, Sergei E. ; Krylova, Yulia S. ; Yablonskiy , Petr K. .

In: Biomedicines, No. 10, 3062, 2022.

Research output: Contribution to journal › Article › peer-review

Harvard

Muraviov, AN, Vinogradova, TI, Remezova, AN, Ariel, BM, Gorelova, AA, Orlova , NV, Yudintceva , NM, Esmedliaeva, DS, Dyakova , ME, Dogonadze, MZ, Zabolotnykh , NV, Garapach, IA, Maslak , OS, Kirillov, YA, Timofeev, SE, Krylova, YS & Yablonskiy , PK 2022, 'The Use of Mesenchymal Stem Cells in the Complex Treatment of Kidney Tuberculosis (Experimental Study)', Biomedicines, no. 10, 3062.

APA

Muraviov, A. N., Vinogradova, T. I., Remezova, A. N., Ariel, B. M., Gorelova, A. A., Orlova , N. V., Yudintceva , N. M., Esmedliaeva, D. S., Dyakova , M. E., Dogonadze, M. Z., Zabolotnykh , N. V., Garapach, I. A., Maslak , O. S., Kirillov, Y. A., Timofeev, S. E., Krylova, Y. S., & Yablonskiy , P. K. (2022). The Use of Mesenchymal Stem Cells in the Complex Treatment of Kidney Tuberculosis (Experimental Study). Biomedicines, (10), [3062].

Vancouver

Muraviov AN, Vinogradova TI, Remezova AN, Ariel BM, Gorelova AA, Orlova NV et al. The Use of Mesenchymal Stem Cells in the Complex Treatment of Kidney Tuberculosis (Experimental Study). Biomedicines. 2022;(10). 3062.

Author

Muraviov, Alexander N. ; Vinogradova, Tatiana I. ; Remezova, Anna N. ; Ariel, Boris M. ; Gorelova, Anna A. ; Orlova , Nadezhda V. ; Yudintceva , Natalia M. ; Esmedliaeva, Diljara S. ; Dyakova , Marina E. ; Dogonadze, Marine Z. ; Zabolotnykh , Natalia V. ; Garapach, Irina A. ; Maslak , Olga S. ; Kirillov, Yuri A. ; Timofeev, Sergei E. ; Krylova, Yulia S. ; Yablonskiy , Petr K. . / The Use of Mesenchymal Stem Cells in the Complex Treatment of Kidney Tuberculosis (Experimental Study). In: Biomedicines. 2022 ; No. 10.

BibTeX

@article{5654657fc8dd4893a5a4b7c71d0a2010,
title = "The Use of Mesenchymal Stem Cells in the Complex Treatment of Kidney Tuberculosis (Experimental Study)",
abstract = "In recent years, the application of mesenchymal stem cells (MSCs) has been recognized as a promising method for treatment of different diseases associated with inflammation and sclerosis, which include nephrotuberculosis. The aim of our study is to investigate the effectiveness of MSCs in the complex therapy of experimental rabbit kidney tuberculosis and to evaluate the effect of cell therapy on the reparative processes. Methods: To simulate kidney tuberculosis, a suspension of the standard strain Mycobacterium tuberculosis H37Rv (106 CFU) was used, which was injected into the cortical layer of the lower pole parenchyma of the left kidney under ultrasound control in rabbits. Anti-tuberculosis therapy (aTBT) was started on the 18th day after infection. MSCs (5 × 107 cells) were transplanted intravenously after the start of aTBT. Results: 2.5 months after infection, all animals showed renal failure. Conducted aTBT significantly reduced the level of albumin, ceruloplasmin, elastase and the severity of disorders in the proteinase/inhibitor system and increased the productive nature of inflammation. A month after MSC transplantation, the level of inflammatory reaction activity proteins decreased, the area of specific and destructive inflammation in kidneys decreased and the formation of mature connective tissue was noted, which indicates the reparative reaction activation.",
keywords = "experimental nephrotuberculosis, MSC, reparative reaction",
author = "Muraviov, {Alexander N.} and Vinogradova, {Tatiana I.} and Remezova, {Anna N.} and Ariel, {Boris M.} and Gorelova, {Anna A.} and Orlova, {Nadezhda V.} and Yudintceva, {Natalia M.} and Esmedliaeva, {Diljara S.} and Dyakova, {Marina E.} and Dogonadze, {Marine Z.} and Zabolotnykh, {Natalia V.} and Garapach, {Irina A.} and Maslak, {Olga S.} and Kirillov, {Yuri A.} and Timofeev, {Sergei E.} and Krylova, {Yulia S.} and Yablonskiy, {Petr K.}",
year = "2022",
language = "English",
journal = "Biomedicines",
issn = "2227-9059",
publisher = "MDPI AG",
number = "10",

}

RIS

TY - JOUR

T1 - The Use of Mesenchymal Stem Cells in the Complex Treatment of Kidney Tuberculosis (Experimental Study)

AU - Muraviov, Alexander N.

AU - Vinogradova, Tatiana I.

AU - Remezova, Anna N.

AU - Ariel, Boris M.

AU - Gorelova, Anna A.

AU - Orlova , Nadezhda V.

AU - Yudintceva , Natalia M.

AU - Esmedliaeva, Diljara S.

AU - Dyakova , Marina E.

AU - Dogonadze, Marine Z.

AU - Zabolotnykh , Natalia V.

AU - Garapach, Irina A.

AU - Maslak , Olga S.

AU - Kirillov, Yuri A.

AU - Timofeev, Sergei E.

AU - Krylova, Yulia S.

AU - Yablonskiy , Petr K.

PY - 2022

Y1 - 2022

N2 - In recent years, the application of mesenchymal stem cells (MSCs) has been recognized as a promising method for treatment of different diseases associated with inflammation and sclerosis, which include nephrotuberculosis. The aim of our study is to investigate the effectiveness of MSCs in the complex therapy of experimental rabbit kidney tuberculosis and to evaluate the effect of cell therapy on the reparative processes. Methods: To simulate kidney tuberculosis, a suspension of the standard strain Mycobacterium tuberculosis H37Rv (106 CFU) was used, which was injected into the cortical layer of the lower pole parenchyma of the left kidney under ultrasound control in rabbits. Anti-tuberculosis therapy (aTBT) was started on the 18th day after infection. MSCs (5 × 107 cells) were transplanted intravenously after the start of aTBT. Results: 2.5 months after infection, all animals showed renal failure. Conducted aTBT significantly reduced the level of albumin, ceruloplasmin, elastase and the severity of disorders in the proteinase/inhibitor system and increased the productive nature of inflammation. A month after MSC transplantation, the level of inflammatory reaction activity proteins decreased, the area of specific and destructive inflammation in kidneys decreased and the formation of mature connective tissue was noted, which indicates the reparative reaction activation.

AB - In recent years, the application of mesenchymal stem cells (MSCs) has been recognized as a promising method for treatment of different diseases associated with inflammation and sclerosis, which include nephrotuberculosis. The aim of our study is to investigate the effectiveness of MSCs in the complex therapy of experimental rabbit kidney tuberculosis and to evaluate the effect of cell therapy on the reparative processes. Methods: To simulate kidney tuberculosis, a suspension of the standard strain Mycobacterium tuberculosis H37Rv (106 CFU) was used, which was injected into the cortical layer of the lower pole parenchyma of the left kidney under ultrasound control in rabbits. Anti-tuberculosis therapy (aTBT) was started on the 18th day after infection. MSCs (5 × 107 cells) were transplanted intravenously after the start of aTBT. Results: 2.5 months after infection, all animals showed renal failure. Conducted aTBT significantly reduced the level of albumin, ceruloplasmin, elastase and the severity of disorders in the proteinase/inhibitor system and increased the productive nature of inflammation. A month after MSC transplantation, the level of inflammatory reaction activity proteins decreased, the area of specific and destructive inflammation in kidneys decreased and the formation of mature connective tissue was noted, which indicates the reparative reaction activation.

KW - experimental nephrotuberculosis

KW - MSC

KW - reparative reaction

UR - https://www.mdpi.com/2227-9059/10/12/3062

M3 - Article

JO - Biomedicines

JF - Biomedicines

SN - 2227-9059

IS - 10

M1 - 3062

ER -

ID: 100797873