The first example of the Büchner-Curtius-Schlotterbeck reaction of cyclic ketones with a stabilized cyclic diazo compound partner is described. The approach towards spirocyclic scaffolds has been exemplified with readily available ∝-diazo-γ-butyrolactone. The reaction proved to be viable with BF 3∙OEt 2 as the preferred catalyst and displayed substantial sensitivity to the size of the cyclic ketone.

Original languageEnglish
Pages (from-to)1800-1802
Number of pages3
JournalTetrahedron Letters
Volume60
Issue number27
DOIs
StatePublished - 4 Jul 2019

    Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

    Research areas

  • Büchner-Curtius-Schlotterbeck reaction, Diazo lactone, Ring expansion, Spirocyclic compounds

ID: 44840419