Research output: Contribution to journal › Article › peer-review
The synthesis and study of carbonic anhydrase activity of sulfonamide-containing dibenzo[1,4]thiazepines. / Смирнова, Дарья Сергеевна; Шаройко, Владимир Владимирович; Калинин, Станислав Алексеевич; Сапегин, Александр Владимирович.
In: Chemistry of Heterocyclic Compounds, Vol. 59, No. 11-12, 09.01.2024, p. 833-838.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - The synthesis and study of carbonic anhydrase activity of sulfonamide-containing dibenzo[1,4]thiazepines
AU - Смирнова, Дарья Сергеевна
AU - Шаройко, Владимир Владимирович
AU - Калинин, Станислав Алексеевич
AU - Сапегин, Александр Владимирович
PY - 2024/1/9
Y1 - 2024/1/9
N2 - A one-pot synthesis approach to access sulfonamide-containing derivatives of dibenzo[1,4]thiazepine using primary amines and 2-[(2-nitro-4-sulfamoylphenyl)sulfanyl]benzoic acid as precursors was developed. The approach is based on a sequence of amidation steps and the subsequent tandem of the Smiles rearrangement and denitrocyclization reaction. The resulting tricyclic systems showed pronounced activity as inhibitors of bovine carbonic anhydrase isoform II.
AB - A one-pot synthesis approach to access sulfonamide-containing derivatives of dibenzo[1,4]thiazepine using primary amines and 2-[(2-nitro-4-sulfamoylphenyl)sulfanyl]benzoic acid as precursors was developed. The approach is based on a sequence of amidation steps and the subsequent tandem of the Smiles rearrangement and denitrocyclization reaction. The resulting tricyclic systems showed pronounced activity as inhibitors of bovine carbonic anhydrase isoform II.
UR - https://www.mendeley.com/catalogue/037eaa38-650b-3d22-9604-f3a7ad82db23/
U2 - 10.1007/s10593-024-03279-2
DO - 10.1007/s10593-024-03279-2
M3 - Article
VL - 59
SP - 833
EP - 838
JO - Chemistry of Heterocyclic Compounds
JF - Chemistry of Heterocyclic Compounds
SN - 0009-3122
IS - 11-12
ER -
ID: 115629937