The Role of Satellite DNA in Causing Structural Rearrangements in Human Karyotype.

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The Role of Satellite DNA in Causing Structural Rearrangements in Human Karyotype. / Пуппо, Ирина Леонидовна; Saifitdinova, A.F.; Tonyan, Z.N.

In: Russian Journal of Genetics, Vol. 56, No. 1, 2020, p. 41-47.

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Author

Пуппо, Ирина Леонидовна ; Saifitdinova, A.F. ; Tonyan, Z.N. / The Role of Satellite DNA in Causing Structural Rearrangements in Human Karyotype. In: Russian Journal of Genetics. 2020 ; Vol. 56, No. 1. pp. 41-47.

BibTeX

@article{c29d5e3403f6446a9e84d3f6921c7052,

title = "The Role of Satellite DNA in Causing Structural Rearrangements in Human Karyotype.",

abstract = "Satellite DNA, whose monomers form long arrays of tandem repeat ranging from hundreds or thousands of copies to several million base pairs, makes up at least 10% of the human genome. Application of new methods of sequencing and bioinformatics analysis opens the way to investigate the organization and functioning of human satellite DNA and contributes to the revision of the long-standing view about this part of the genome as “junk DNA.” One of the important features of satellite DNA is its participation in structural rearrangements in the human karyotype. This review examines the mechanisms of participation of satellite DNA in the formation of structural rearrangements, as well as the nature of transcription of tandem repeats in structural rearrangements in the karyotype of normal and tumor cells.",

keywords = "chromosomal rearrangements, double-strand breaks, noncoding DNA transcription, satellite DNA, chromosomal rearrangements, double-strand breaks, noncoding DNA transcription, satellite DNA",

author = "Пуппо, {Ирина Леонидовна} and A.F. Saifitdinova and Z.N. Tonyan",

year = "2020",

language = "English",

volume = "56",

pages = "41--47",

journal = "Russian Journal of Genetics",

issn = "1022-7954",

publisher = "МАИК {"}Наука/Интерпериодика{"}",

number = "1",

}

RIS

TY - JOUR

T1 - The Role of Satellite DNA in Causing Structural Rearrangements in Human Karyotype.

AU - Пуппо, Ирина Леонидовна

AU - Saifitdinova, A.F.

AU - Tonyan, Z.N.

PY - 2020

Y1 - 2020

N2 - Satellite DNA, whose monomers form long arrays of tandem repeat ranging from hundreds or thousands of copies to several million base pairs, makes up at least 10% of the human genome. Application of new methods of sequencing and bioinformatics analysis opens the way to investigate the organization and functioning of human satellite DNA and contributes to the revision of the long-standing view about this part of the genome as “junk DNA.” One of the important features of satellite DNA is its participation in structural rearrangements in the human karyotype. This review examines the mechanisms of participation of satellite DNA in the formation of structural rearrangements, as well as the nature of transcription of tandem repeats in structural rearrangements in the karyotype of normal and tumor cells.

AB - Satellite DNA, whose monomers form long arrays of tandem repeat ranging from hundreds or thousands of copies to several million base pairs, makes up at least 10% of the human genome. Application of new methods of sequencing and bioinformatics analysis opens the way to investigate the organization and functioning of human satellite DNA and contributes to the revision of the long-standing view about this part of the genome as “junk DNA.” One of the important features of satellite DNA is its participation in structural rearrangements in the human karyotype. This review examines the mechanisms of participation of satellite DNA in the formation of structural rearrangements, as well as the nature of transcription of tandem repeats in structural rearrangements in the karyotype of normal and tumor cells.

KW - chromosomal rearrangements

KW - double-strand breaks

KW - noncoding DNA transcription

KW - satellite DNA

KW - chromosomal rearrangements

KW - double-strand breaks

KW - noncoding DNA transcription

KW - satellite DNA

M3 - Article

VL - 56

SP - 41

EP - 47

JO - Russian Journal of Genetics

JF - Russian Journal of Genetics

SN - 1022-7954

IS - 1

ER -

ID: 78599281