The present paper considers daily hassles in different life domains, reveals their connections to the level of strain and perceived stress, investigates the role of psychological well-being and life satisfaction in the perception of the number of stressors and strain caused by stress. Methods: Inventory of daily stressors (Petrash et al.), Scale of perceived stress (Ababkov et al.), Psychological well-being scale (C. Ryff), Life satisfaction scale (E. Diener), a survey on satisfaction with different life domains. Sample: 334 adults aged 20-60 (118 males, 216 females). Results revealed hassles in all the life domains. Most pronounced hassles in women were those related to health, loneliness, competitiveness, job; most pronounced hassles in men were job-related, financial, health and family stressors. Perception of daily hassles was associated with an increase in the levels of stress overstrain and perceived stress. The number of stressors and the level of overstrain was higher in women. Psychological well-being, subjective well-being, and financial satisfaction were shown to be direct positive predictors of the number of perceived hassles and the level of overstrain.