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The role of omega-3 polyunsaturated fatty acids eicosapentaenoic and docosahexaenoic acids in the treatment of major depression and Alzheimer's disease : Acting separately or synergistically? / Song, Cai; Shieh, Chu Hsin; Wu, Yi Shyuan; Kalueff, Allan; Gaikwad, Siddharth; Su, Kuan Pin.

In: Progress in Lipid Research, Vol. 62, 01.04.2016, p. 41-54.

Research output: Contribution to journal › Review article › peer-review

Harvard

Song, C, Shieh, CH, Wu, YS, Kalueff, A, Gaikwad, S & Su, KP 2016, 'The role of omega-3 polyunsaturated fatty acids eicosapentaenoic and docosahexaenoic acids in the treatment of major depression and Alzheimer's disease: Acting separately or synergistically?', Progress in Lipid Research, vol. 62, pp. 41-54. https://doi.org/10.1016/j.plipres.2015.12.003

APA

Song, C., Shieh, C. H., Wu, Y. S., Kalueff, A., Gaikwad, S., & Su, K. P. (2016). The role of omega-3 polyunsaturated fatty acids eicosapentaenoic and docosahexaenoic acids in the treatment of major depression and Alzheimer's disease: Acting separately or synergistically? Progress in Lipid Research, 62, 41-54. https://doi.org/10.1016/j.plipres.2015.12.003

Vancouver

Song C, Shieh CH, Wu YS, Kalueff A, Gaikwad S, Su KP. The role of omega-3 polyunsaturated fatty acids eicosapentaenoic and docosahexaenoic acids in the treatment of major depression and Alzheimer's disease: Acting separately or synergistically? Progress in Lipid Research. 2016 Apr 1;62:41-54. https://doi.org/10.1016/j.plipres.2015.12.003

Author

Song, Cai ; Shieh, Chu Hsin ; Wu, Yi Shyuan ; Kalueff, Allan ; Gaikwad, Siddharth ; Su, Kuan Pin. / The role of omega-3 polyunsaturated fatty acids eicosapentaenoic and docosahexaenoic acids in the treatment of major depression and Alzheimer's disease : Acting separately or synergistically?. In: Progress in Lipid Research. 2016 ; Vol. 62. pp. 41-54.

BibTeX

@article{1846cddfed524c23885f3befa189f5eb,
title = "The role of omega-3 polyunsaturated fatty acids eicosapentaenoic and docosahexaenoic acids in the treatment of major depression and Alzheimer's disease: Acting separately or synergistically?",
abstract = "Omega-3 polyunsaturated fatty acids (n-3-PUFAs), mainly eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), may improve or prevent some psychiatric and neurodegenerative diseases in both experimental and clinical studies. As important membrane components, these PUFAs benefit brain health by modulating neuroimmune and apoptotic pathways, changing membrane function and/or competing with n-6 PUFAs, the precursors of inflammatory mediators. However, the exact role of each fatty acid in neuroimmune modulation and neurogenesis, the interaction between EPA and DHA, and the best EPA:DHA ratios for improving brain disorders, remain unclear. It is also unknown whether EPA, as a DHA precursor, acts directly or via DHA. Here, we discuss recent evidence of EPA and DHA effects in the treatment of major depression and Alzheimer's disease, as well as their potential synergistic action on anti-inflammatory, antioxidant and neurotrophic processes in the brain. We further analyze the cellular and molecular mechanisms by which EPA, DHA or their combination may benefit these diseases. We also outline the limitations of current studies and suggest new genetic models and novel approaches to overcome these limitations. Finally, we summarize future strategies for translational research in this field.",
keywords = "Alzheimer's disease, Docosahexaenoic acid, Eicosapentaenoic acid, Inflammation, Major depressive disorder, Neurogenesis",
author = "Cai Song and Shieh, {Chu Hsin} and Wu, {Yi Shyuan} and Allan Kalueff and Siddharth Gaikwad and Su, {Kuan Pin}",
year = "2016",
month = apr,
day = "1",
doi = "10.1016/j.plipres.2015.12.003",
language = "English",
volume = "62",
pages = "41--54",
journal = "Progress in Lipid Research",
issn = "0163-7827",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - The role of omega-3 polyunsaturated fatty acids eicosapentaenoic and docosahexaenoic acids in the treatment of major depression and Alzheimer's disease

T2 - Acting separately or synergistically?

AU - Song, Cai

AU - Shieh, Chu Hsin

AU - Wu, Yi Shyuan

AU - Kalueff, Allan

AU - Gaikwad, Siddharth

AU - Su, Kuan Pin

PY - 2016/4/1

Y1 - 2016/4/1

N2 - Omega-3 polyunsaturated fatty acids (n-3-PUFAs), mainly eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), may improve or prevent some psychiatric and neurodegenerative diseases in both experimental and clinical studies. As important membrane components, these PUFAs benefit brain health by modulating neuroimmune and apoptotic pathways, changing membrane function and/or competing with n-6 PUFAs, the precursors of inflammatory mediators. However, the exact role of each fatty acid in neuroimmune modulation and neurogenesis, the interaction between EPA and DHA, and the best EPA:DHA ratios for improving brain disorders, remain unclear. It is also unknown whether EPA, as a DHA precursor, acts directly or via DHA. Here, we discuss recent evidence of EPA and DHA effects in the treatment of major depression and Alzheimer's disease, as well as their potential synergistic action on anti-inflammatory, antioxidant and neurotrophic processes in the brain. We further analyze the cellular and molecular mechanisms by which EPA, DHA or their combination may benefit these diseases. We also outline the limitations of current studies and suggest new genetic models and novel approaches to overcome these limitations. Finally, we summarize future strategies for translational research in this field.

AB - Omega-3 polyunsaturated fatty acids (n-3-PUFAs), mainly eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), may improve or prevent some psychiatric and neurodegenerative diseases in both experimental and clinical studies. As important membrane components, these PUFAs benefit brain health by modulating neuroimmune and apoptotic pathways, changing membrane function and/or competing with n-6 PUFAs, the precursors of inflammatory mediators. However, the exact role of each fatty acid in neuroimmune modulation and neurogenesis, the interaction between EPA and DHA, and the best EPA:DHA ratios for improving brain disorders, remain unclear. It is also unknown whether EPA, as a DHA precursor, acts directly or via DHA. Here, we discuss recent evidence of EPA and DHA effects in the treatment of major depression and Alzheimer's disease, as well as their potential synergistic action on anti-inflammatory, antioxidant and neurotrophic processes in the brain. We further analyze the cellular and molecular mechanisms by which EPA, DHA or their combination may benefit these diseases. We also outline the limitations of current studies and suggest new genetic models and novel approaches to overcome these limitations. Finally, we summarize future strategies for translational research in this field.

KW - Alzheimer's disease

KW - Docosahexaenoic acid

KW - Eicosapentaenoic acid

KW - Inflammation

KW - Major depressive disorder

KW - Neurogenesis

UR - http://www.scopus.com/inward/record.url?scp=84955317668&partnerID=8YFLogxK

U2 - 10.1016/j.plipres.2015.12.003

DO - 10.1016/j.plipres.2015.12.003

M3 - Review article

C2 - 26763196

AN - SCOPUS:84955317668

VL - 62

SP - 41

EP - 54

JO - Progress in Lipid Research

JF - Progress in Lipid Research

SN - 0163-7827

ER -

ID: 9435381