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The role of intraspecies variation in fish neurobehavioral and neuropharmacological phenotypes in aquatic models. / Demin, Konstantin A.; Lakstygal, Anton M.; Alekseeva, Polina A.; Sysoev, Maxim; de Abreu, Murilo S.; Alpyshov, Erik T.; Serikuly, Nazar; Wang, Dong Mei; Wang, Meng Yao; Tang, Zhi Chong; Yan, Dong Ni; Strekalova, Tatyana V.; Volgin, Andrey D.; Amstislavskaya, Tamara G.; Wang, Jia Jia; Song, Cai; Kalueff, Allan V.

In: Aquatic Toxicology, Vol. 210, 01.05.2019, p. 44-55.

Research output: Contribution to journal › Article › peer-review

Harvard

Demin, KA, Lakstygal, AM, Alekseeva, PA, Sysoev, M, de Abreu, MS, Alpyshov, ET, Serikuly, N, Wang, DM, Wang, MY, Tang, ZC, Yan, DN, Strekalova, TV, Volgin, AD, Amstislavskaya, TG, Wang, JJ, Song, C & Kalueff, AV 2019, 'The role of intraspecies variation in fish neurobehavioral and neuropharmacological phenotypes in aquatic models', Aquatic Toxicology, vol. 210, pp. 44-55. https://doi.org/10.1016/j.aquatox.2019.02.015

APA

Demin, K. A., Lakstygal, A. M., Alekseeva, P. A., Sysoev, M., de Abreu, M. S., Alpyshov, E. T., Serikuly, N., Wang, D. M., Wang, M. Y., Tang, Z. C., Yan, D. N., Strekalova, T. V., Volgin, A. D., Amstislavskaya, T. G., Wang, J. J., Song, C., & Kalueff, A. V. (2019). The role of intraspecies variation in fish neurobehavioral and neuropharmacological phenotypes in aquatic models. Aquatic Toxicology, 210, 44-55. https://doi.org/10.1016/j.aquatox.2019.02.015

Vancouver

Demin KA, Lakstygal AM, Alekseeva PA, Sysoev M, de Abreu MS, Alpyshov ET et al. The role of intraspecies variation in fish neurobehavioral and neuropharmacological phenotypes in aquatic models. Aquatic Toxicology. 2019 May 1;210:44-55. https://doi.org/10.1016/j.aquatox.2019.02.015

Author

Demin, Konstantin A. ; Lakstygal, Anton M. ; Alekseeva, Polina A. ; Sysoev, Maxim ; de Abreu, Murilo S. ; Alpyshov, Erik T. ; Serikuly, Nazar ; Wang, Dong Mei ; Wang, Meng Yao ; Tang, Zhi Chong ; Yan, Dong Ni ; Strekalova, Tatyana V. ; Volgin, Andrey D. ; Amstislavskaya, Tamara G. ; Wang, Jia Jia ; Song, Cai ; Kalueff, Allan V. / The role of intraspecies variation in fish neurobehavioral and neuropharmacological phenotypes in aquatic models. In: Aquatic Toxicology. 2019 ; Vol. 210. pp. 44-55.

BibTeX

@article{ca3601e752a347ffa26c214952ee1e0c,
title = "The role of intraspecies variation in fish neurobehavioral and neuropharmacological phenotypes in aquatic models",
abstract = "Intraspecies variation is common in both clinical and animal research of various brain disorders. Relatively well-studied in mammals, intraspecies variation in aquatic fish models and its role in their behavioral and pharmacological responses remain poorly understood. Like humans and mammals, fishes show high variance of behavioral and drug-evoked responses, modulated both genetically and environmentally. The zebrafish (Danio rerio) has emerged as a particularly useful model organism tool to access neurobehavioral and drug-evoked responses. Here, we discuss recent findings and the role of the intraspecies variance in neurobehavioral, pharmacological and toxicological studies utilizing zebrafish and other fish models. We also critically evaluate common sources of intraspecies variation and outline potential strategies to improve data reproducibility and translatability.",
keywords = "Aquatic models, Individuality, Intraspecies variation, Neurobehavioral variation, Zebrafish, Reproducibility of Results, Species Specificity, Humans, Nervous System Physiological Phenomena/drug effects, Sex Characteristics, Zebrafish/genetics, Gene-Environment Interaction, Phenotype, Animals, Behavior, Animal/drug effects, Models, Biological, Water Pollutants, Chemical/toxicity, ZEBRAFISH DANIO-RERIO, GENE-ENVIRONMENT INTERACTIONS, ANIMAL-MODELS, WILD-TYPE ZEBRAFISH, JUVENILE RAINBOW-TROUT, RISK-TAKING, GUT MICROBIOTA, ADULT ZEBRAFISH, INDIVIDUAL-DIFFERENCES, SEX-DIFFERENCES",
author = "Demin, {Konstantin A.} and Lakstygal, {Anton M.} and Alekseeva, {Polina A.} and Maxim Sysoev and {de Abreu}, {Murilo S.} and Alpyshov, {Erik T.} and Nazar Serikuly and Wang, {Dong Mei} and Wang, {Meng Yao} and Tang, {Zhi Chong} and Yan, {Dong Ni} and Strekalova, {Tatyana V.} and Volgin, {Andrey D.} and Amstislavskaya, {Tamara G.} and Wang, {Jia Jia} and Cai Song and Kalueff, {Allan V.}",
year = "2019",
month = may,
day = "1",
doi = "10.1016/j.aquatox.2019.02.015",
language = "English",
volume = "210",
pages = "44--55",
journal = "Aquatic Toxicology",
issn = "0166-445X",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - The role of intraspecies variation in fish neurobehavioral and neuropharmacological phenotypes in aquatic models

AU - Demin, Konstantin A.

AU - Lakstygal, Anton M.

AU - Alekseeva, Polina A.

AU - Sysoev, Maxim

AU - de Abreu, Murilo S.

AU - Alpyshov, Erik T.

AU - Serikuly, Nazar

AU - Wang, Dong Mei

AU - Wang, Meng Yao

AU - Tang, Zhi Chong

AU - Yan, Dong Ni

AU - Strekalova, Tatyana V.

AU - Volgin, Andrey D.

AU - Amstislavskaya, Tamara G.

AU - Wang, Jia Jia

AU - Song, Cai

AU - Kalueff, Allan V.

PY - 2019/5/1

Y1 - 2019/5/1

N2 - Intraspecies variation is common in both clinical and animal research of various brain disorders. Relatively well-studied in mammals, intraspecies variation in aquatic fish models and its role in their behavioral and pharmacological responses remain poorly understood. Like humans and mammals, fishes show high variance of behavioral and drug-evoked responses, modulated both genetically and environmentally. The zebrafish (Danio rerio) has emerged as a particularly useful model organism tool to access neurobehavioral and drug-evoked responses. Here, we discuss recent findings and the role of the intraspecies variance in neurobehavioral, pharmacological and toxicological studies utilizing zebrafish and other fish models. We also critically evaluate common sources of intraspecies variation and outline potential strategies to improve data reproducibility and translatability.

AB - Intraspecies variation is common in both clinical and animal research of various brain disorders. Relatively well-studied in mammals, intraspecies variation in aquatic fish models and its role in their behavioral and pharmacological responses remain poorly understood. Like humans and mammals, fishes show high variance of behavioral and drug-evoked responses, modulated both genetically and environmentally. The zebrafish (Danio rerio) has emerged as a particularly useful model organism tool to access neurobehavioral and drug-evoked responses. Here, we discuss recent findings and the role of the intraspecies variance in neurobehavioral, pharmacological and toxicological studies utilizing zebrafish and other fish models. We also critically evaluate common sources of intraspecies variation and outline potential strategies to improve data reproducibility and translatability.

KW - Aquatic models

KW - Individuality

KW - Intraspecies variation

KW - Neurobehavioral variation

KW - Zebrafish

KW - Reproducibility of Results

KW - Species Specificity

KW - Humans

KW - Nervous System Physiological Phenomena/drug effects

KW - Sex Characteristics

KW - Zebrafish/genetics

KW - Gene-Environment Interaction

KW - Phenotype

KW - Animals

KW - Behavior, Animal/drug effects

KW - Models, Biological

KW - Water Pollutants, Chemical/toxicity

KW - ZEBRAFISH DANIO-RERIO

KW - GENE-ENVIRONMENT INTERACTIONS

KW - ANIMAL-MODELS

KW - WILD-TYPE ZEBRAFISH

KW - JUVENILE RAINBOW-TROUT

KW - RISK-TAKING

KW - GUT MICROBIOTA

KW - ADULT ZEBRAFISH

KW - INDIVIDUAL-DIFFERENCES

KW - SEX-DIFFERENCES

UR - http://www.scopus.com/inward/record.url?scp=85062040499&partnerID=8YFLogxK

UR - http://www.mendeley.com/research/role-intraspecies-variation-fish-neurobehavioral-neuropharmacological-phenotypes-aquatic-models

U2 - 10.1016/j.aquatox.2019.02.015

DO - 10.1016/j.aquatox.2019.02.015

M3 - Article

C2 - 30822702

AN - SCOPUS:85062040499

VL - 210

SP - 44

EP - 55

JO - Aquatic Toxicology

JF - Aquatic Toxicology

SN - 0166-445X

ER -

ID: 47609969