The role of D1-dependent dopaminergic mechanisms of the frontal cortex in delayed responding in rats

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The role of D1-dependent dopaminergic mechanisms of the frontal cortex in delayed responding in rats. / Kozlov, A. P.; Druzin, M. Ya; Kurzina, N. P.; Malinina, E. P.

In: Neuroscience and Behavioral Physiology, Vol. 31, No. 4, 29.08.2001, p. 405-411.

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Author

Kozlov, A. P. ; Druzin, M. Ya ; Kurzina, N. P. ; Malinina, E. P. / The role of D1-dependent dopaminergic mechanisms of the frontal cortex in delayed responding in rats. In: Neuroscience and Behavioral Physiology. 2001 ; Vol. 31, No. 4. pp. 405-411.

BibTeX

@article{0a44f502ec894ca1b5c5493df3889a2e,

title = "The role of D1-dependent dopaminergic mechanisms of the frontal cortex in delayed responding in rats",

abstract = "The effects of local microinjections of D1-selective dopaminergic agents into the medial wall of the frontal cortex of rats on short-term memory processes were studied, along with the effects of proactive interference in immediate and delayed spatial choice tasks in a Y maze. Microinjections of the D1 receptor antagonist SCH23390 (1 nmol) disturbed performance of both immediate and delayed choice tasks, while administration of the D1 receptor agonist SKF38393 (1 nmol) had no effect on immediate choice and improved delayed performance. The effects of proactive interference, induced by microinjections of SCH23390 and SKF38393 into the frontal cortex, were significantly more marked in delayed choice than in the non-delayed task. Administration of SCH23390 increased the number of erroneous excursions made by the animals, the directions of these excursions coinciding with the preferred direction of rotation of the animals in a rotation test. The results obtained here lead to the conclusion that blockade of dopaminergic transmission in the mediofrontal cortex of rats worsens the performance of spatial choice in a Y maze by strengthening proactive interference processes and disinhibiting the mechanisms which internally prepare the animals to respond to a defined spatial direction with behavioral acts.",

author = "Kozlov, {A. P.} and Druzin, {M. Ya} and Kurzina, {N. P.} and Malinina, {E. P.}",

year = "2001",

month = aug,

day = "29",

doi = "10.1023/A:1010488612338",

language = "English",

volume = "31",

pages = "405--411",

journal = "Neuroscience and Behavioral Physiology",

issn = "0097-0549",

publisher = "Springer Nature",

number = "4",

}

RIS

TY - JOUR

T1 - The role of D1-dependent dopaminergic mechanisms of the frontal cortex in delayed responding in rats

AU - Kozlov, A. P.

AU - Druzin, M. Ya

AU - Kurzina, N. P.

AU - Malinina, E. P.

PY - 2001/8/29

Y1 - 2001/8/29

N2 - The effects of local microinjections of D1-selective dopaminergic agents into the medial wall of the frontal cortex of rats on short-term memory processes were studied, along with the effects of proactive interference in immediate and delayed spatial choice tasks in a Y maze. Microinjections of the D1 receptor antagonist SCH23390 (1 nmol) disturbed performance of both immediate and delayed choice tasks, while administration of the D1 receptor agonist SKF38393 (1 nmol) had no effect on immediate choice and improved delayed performance. The effects of proactive interference, induced by microinjections of SCH23390 and SKF38393 into the frontal cortex, were significantly more marked in delayed choice than in the non-delayed task. Administration of SCH23390 increased the number of erroneous excursions made by the animals, the directions of these excursions coinciding with the preferred direction of rotation of the animals in a rotation test. The results obtained here lead to the conclusion that blockade of dopaminergic transmission in the mediofrontal cortex of rats worsens the performance of spatial choice in a Y maze by strengthening proactive interference processes and disinhibiting the mechanisms which internally prepare the animals to respond to a defined spatial direction with behavioral acts.

AB - The effects of local microinjections of D1-selective dopaminergic agents into the medial wall of the frontal cortex of rats on short-term memory processes were studied, along with the effects of proactive interference in immediate and delayed spatial choice tasks in a Y maze. Microinjections of the D1 receptor antagonist SCH23390 (1 nmol) disturbed performance of both immediate and delayed choice tasks, while administration of the D1 receptor agonist SKF38393 (1 nmol) had no effect on immediate choice and improved delayed performance. The effects of proactive interference, induced by microinjections of SCH23390 and SKF38393 into the frontal cortex, were significantly more marked in delayed choice than in the non-delayed task. Administration of SCH23390 increased the number of erroneous excursions made by the animals, the directions of these excursions coinciding with the preferred direction of rotation of the animals in a rotation test. The results obtained here lead to the conclusion that blockade of dopaminergic transmission in the mediofrontal cortex of rats worsens the performance of spatial choice in a Y maze by strengthening proactive interference processes and disinhibiting the mechanisms which internally prepare the animals to respond to a defined spatial direction with behavioral acts.

UR - http://www.scopus.com/inward/record.url?scp=0034870453&partnerID=8YFLogxK

U2 - 10.1023/A:1010488612338

DO - 10.1023/A:1010488612338

M3 - Article

C2 - 11508491

AN - SCOPUS:0034870453

VL - 31

SP - 405

EP - 411

JO - Neuroscience and Behavioral Physiology

JF - Neuroscience and Behavioral Physiology

SN - 0097-0549

IS - 4

ER -

ID: 36393352