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The role of D1 dopamine receptors in rat medial frontal cortex in delayed performance. / Kozlov, A. P.; Druzin, M. Ya; Kurzina, N. P.; Malinina, E. P.

In: Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I.P. Pavlova, Vol. 50, No. 4, 01.01.2000, p. 665-666.

Research output: Contribution to journal › Article › peer-review

Harvard

Kozlov, AP, Druzin, MY, Kurzina, NP & Malinina, EP 2000, 'The role of D1 dopamine receptors in rat medial frontal cortex in delayed performance', Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I.P. Pavlova, vol. 50, no. 4, pp. 665-666.

APA

Kozlov, A. P., Druzin, M. Y., Kurzina, N. P., & Malinina, E. P. (2000). The role of D1 dopamine receptors in rat medial frontal cortex in delayed performance. Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I.P. Pavlova, 50(4), 665-666.

Vancouver

Kozlov AP, Druzin MY, Kurzina NP, Malinina EP. The role of D1 dopamine receptors in rat medial frontal cortex in delayed performance. Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I.P. Pavlova. 2000 Jan 1;50(4):665-666.

Author

Kozlov, A. P. ; Druzin, M. Ya ; Kurzina, N. P. ; Malinina, E. P. / The role of D1 dopamine receptors in rat medial frontal cortex in delayed performance. In: Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I.P. Pavlova. 2000 ; Vol. 50, No. 4. pp. 665-666.

BibTeX

@article{e657f62798754cf6bfeb4bf3f478a574,
title = "The role of D1 dopamine receptors in rat medial frontal cortex in delayed performance",
abstract = "The effects of microinjections of D1 selective dopaminergic substances into the medial frontal cortex (MFC) on information storage and proactive interference during delayed (the deay in 3s) and non-delayed choice in Y-maze were studied. Bilateral micromjection of D1 receptor antagonist SCH 23390 (1 nM, 1 μ1) impaired both delayed and non-delayed choice. In contrast, microinjections of D1 receptor agonist SKF 38393 (1 nM) into the MFC significantly improved the delayed peformance and did not influence the non-delayed choice. The effects of proactive interference caused by SCH 23390 and SKF 38393 injections were more pronounced in delayed choice condition than in the non-delayed task. Spatial bias in animal behavior was revealed after the SCH 23390 injections: during erroneous choices rats more frequently turned in the same direction as preferred in a rotation test. The results suggest that impairment of delayed performance in Y-maze observed under the blockade of D1-mediated neurotransmission in the MFC occurs due to enhancement of the processes of proactive interference and disinhibition of the spatial set.",
author = "Kozlov, {A. P.} and Druzin, {M. Ya} and Kurzina, {N. P.} and Malinina, {E. P.}",
year = "2000",
month = jan,
day = "1",
language = "русский",
volume = "50",
pages = "665--666",
journal = "ЖУРНАЛ ВЫСШЕЙ НЕРВНОЙ ДЕЯТЕЛЬНОСТИ ИМ. И.П. ПАВЛОВА",
issn = "0044-4677",
publisher = "Издательство {"}Наука{"}",
number = "4",

}

RIS

TY - JOUR

T1 - The role of D1 dopamine receptors in rat medial frontal cortex in delayed performance

AU - Kozlov, A. P.

AU - Druzin, M. Ya

AU - Kurzina, N. P.

AU - Malinina, E. P.

PY - 2000/1/1

Y1 - 2000/1/1

N2 - The effects of microinjections of D1 selective dopaminergic substances into the medial frontal cortex (MFC) on information storage and proactive interference during delayed (the deay in 3s) and non-delayed choice in Y-maze were studied. Bilateral micromjection of D1 receptor antagonist SCH 23390 (1 nM, 1 μ1) impaired both delayed and non-delayed choice. In contrast, microinjections of D1 receptor agonist SKF 38393 (1 nM) into the MFC significantly improved the delayed peformance and did not influence the non-delayed choice. The effects of proactive interference caused by SCH 23390 and SKF 38393 injections were more pronounced in delayed choice condition than in the non-delayed task. Spatial bias in animal behavior was revealed after the SCH 23390 injections: during erroneous choices rats more frequently turned in the same direction as preferred in a rotation test. The results suggest that impairment of delayed performance in Y-maze observed under the blockade of D1-mediated neurotransmission in the MFC occurs due to enhancement of the processes of proactive interference and disinhibition of the spatial set.

AB - The effects of microinjections of D1 selective dopaminergic substances into the medial frontal cortex (MFC) on information storage and proactive interference during delayed (the deay in 3s) and non-delayed choice in Y-maze were studied. Bilateral micromjection of D1 receptor antagonist SCH 23390 (1 nM, 1 μ1) impaired both delayed and non-delayed choice. In contrast, microinjections of D1 receptor agonist SKF 38393 (1 nM) into the MFC significantly improved the delayed peformance and did not influence the non-delayed choice. The effects of proactive interference caused by SCH 23390 and SKF 38393 injections were more pronounced in delayed choice condition than in the non-delayed task. Spatial bias in animal behavior was revealed after the SCH 23390 injections: during erroneous choices rats more frequently turned in the same direction as preferred in a rotation test. The results suggest that impairment of delayed performance in Y-maze observed under the blockade of D1-mediated neurotransmission in the MFC occurs due to enhancement of the processes of proactive interference and disinhibition of the spatial set.

UR - http://www.scopus.com/inward/record.url?scp=0345850009&partnerID=8YFLogxK

M3 - статья

C2 - 10984910

AN - SCOPUS:0345850009

VL - 50

SP - 665

EP - 666

JO - ЖУРНАЛ ВЫСШЕЙ НЕРВНОЙ ДЕЯТЕЛЬНОСТИ ИМ. И.П. ПАВЛОВА

JF - ЖУРНАЛ ВЫСШЕЙ НЕРВНОЙ ДЕЯТЕЛЬНОСТИ ИМ. И.П. ПАВЛОВА

SN - 0044-4677

IS - 4

ER -

ID: 36393277